维生素D受体基因FokI多态性在椎间盘退变中的分析
Analysis of FokI polymorphism of vitamin D receptor gene in intervertebral disc degeneration.
作者信息
Vieira Luiz Angelo, De Marchi Patricia Leme, dos Santos Aline Amaro, Christofolini Denise Maria, Barbosa Caio Parente, Fonseca Fernando Luiz Affonso, Bianco Bianca, Rodrigues Luciano Miller R
机构信息
1 Division of Orthopedics and Traumatology, Department of Surgery, Faculdade de Medicina do ABC , Santo André/SP, Brazil .
出版信息
Genet Test Mol Biomarkers. 2014 Sep;18(9):625-9. doi: 10.1089/gtmb.2014.0030. Epub 2014 Jul 9.
Abstract
AIM
We have hypothesized a possible relationship between disc degeneration (DD) and VDR FokI/T2C polymorphism.
METHODS
A case-control study was performed comprising 121 Brazilian patients with confirmed DD by nuclear magnetic resonance and a control group consisting of 131 healthy patients without a history of disc cysts of the lumbar spine. Detection of VDR FokI/T2C polymorphism was performed using restriction fragment length polymorphism-polymerase chain reaction. The chi-square test was used to compare allele and genotype frequencies between groups, and a p-value of <0.05 was considered statistically significant.
RESULTS
The results disclosed statistical difference between allele distribution among cases and controls (p=0.025, odds ratio=1.58, confidence interval=1.07-2.32) considering VDR FokI/T2C polymorphism.
CONCLUSION
The results showed a positive association between VDR FokI/T2C polymorphism and DD in Brazilian patients tested.
摘要
目的
我们推测椎间盘退变（DD）与维生素D受体（VDR）FokI/T2C多态性之间可能存在关联。
方法
进行了一项病例对照研究，包括121例经核磁共振确诊为DD的巴西患者，以及一个由131例无腰椎间盘囊肿病史的健康患者组成的对照组。采用限制性片段长度多态性-聚合酶链反应检测VDR FokI/T2C多态性。使用卡方检验比较两组之间的等位基因和基因型频率，p值<0.05被认为具有统计学意义。
结果
考虑VDR FokI/T2C多态性时，病例组和对照组之间的等位基因分布存在统计学差异（p = 0.025，比值比 = 1.58，置信区间 = 1.07 - 2.32）。
结论
结果显示，在接受检测的巴西患者中，VDR FokI/T2C多态性与DD之间存在正相关。
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