Kato J, Kida O, Nakamura S, Sasaki A, Takiguchi K, Tanaka K
Life Sci. 1986 Dec 29;39(26):2623-7. doi: 10.1016/0024-3205(86)90118-9.
To investigate the time course effect of sodium intake on release and synthesis of atrial natriuretic polypeptide (ANP), plasma and atrial content of ANP were measured in rats which had been fed either a high or a low salt diet for 1, 3, 7, 14 and 35 days. Plasma ANP in rats fed the high salt diet for one day was significantly higher than in those fed the low salt diet. However, there were no significant differences between the groups fed either the high or the low salt diet for 3 days or more. In contrast to the direction of change in plasma ANP, atrial content of ANP in rats fed the high salt diet for one day tended to be lower and was significantly lower in those fed for 3 and 7 days than in the low salt diet group, while there were no significant differences between both groups that were fed for 14 and 35 days. These results suggest that ANP is rapidly released into the circulation when sodium is loaded, however, the atrial storage of ANP remains depleted for about one week.
为研究钠摄入对心房利钠多肽（ANP）释放和合成的时程效应，对分别给予高盐或低盐饮食1、3、7、14和35天的大鼠，测定其血浆和心房中ANP的含量。高盐饮食1天的大鼠血浆ANP显著高于低盐饮食的大鼠。然而，高盐或低盐饮食3天及以上的组间无显著差异。与血浆ANP的变化方向相反，高盐饮食1天的大鼠心房ANP含量趋于降低，高盐饮食3天和7天的大鼠心房ANP含量显著低于低盐饮食组，而高盐和低盐饮食14天及35天的两组间无显著差异。这些结果表明，钠负荷时ANP迅速释放入循环，但心房中ANP的储存约一周内仍处于耗竭状态。
