Gutkowska J, Kuchel O, Racz K, Buu N T, Cantin M, Genest J
Biochem Biophys Res Commun. 1986 Apr 14;136(1):411-6. doi: 10.1016/0006-291x(86)90926-5.
We measured the immunoreactive atrial natriuretic factor concentrations in plasma and right and left atria of salt-sensitive, salt-resistant Dahl rats and Wistar Kyoto rats, all fed for 5 weeks by 8% salt diet. We found an increase in plasma immunoreactive atrial natriuretic factor (p less than 0.001) in salt-sensitive Dahl rats which became severely hypertensive in comparison with salt-resistant and Wistar Kyoto rats which remained normotensive on the same diet. There were however, no differences in the immunoreactive atrial natriuretic factor concentrations in the atria between the three groups of rats; all rats tended to have lower concentrations in the left than in the right atrium. The data show the presence of increased circulating atrial natriuretic factor immunoreactivity in hypertensive salt-sensitive Dahl rats which may be due either to the hypertension-induced left atrial distention, to volume expansion or indirectly renal hyposensitivity to the atrial natriuretic factor in these rats.
我们测定了盐敏感型、盐抵抗型 Dahl 大鼠以及 Wistar Kyoto 大鼠血浆和左右心房中免疫反应性心房利钠因子的浓度，所有大鼠均用 8%的盐饮食喂养 5 周。我们发现，与盐抵抗型和 Wistar Kyoto 大鼠相比，盐敏感型 Dahl 大鼠血浆中免疫反应性心房利钠因子增加（p<0.001），在相同饮食条件下，盐敏感型 Dahl 大鼠出现严重高血压，而盐抵抗型和 Wistar Kyoto 大鼠仍保持血压正常。然而，三组大鼠心房中免疫反应性心房利钠因子浓度并无差异；所有大鼠左心房中的浓度往往低于右心房。数据表明，高血压盐敏感型 Dahl 大鼠循环中存在心房利钠因子免疫反应性增加，这可能是由于高血压引起的左心房扩张、容量扩张，或者是这些大鼠肾脏对心房利钠因子间接低敏所致。
