Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Veterans Administration Medical Center, La Jolla, California, USA.
Nat Med. 2018 May;24(4):484-490. doi: 10.1038/nm.4502. Epub 2018 Feb 26.
We grafted human spinal cord-derived neural progenitor cells (NPCs) into sites of cervical spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug immunosuppression, grafts survived at least 9 months postinjury and expressed both neuronal and glial markers. Monkey axons regenerated into grafts and formed synapses. Hundreds of thousands of human axons extended out from grafts through monkey white matter and synapsed in distal gray matter. Grafts gradually matured over 9 months and improved forelimb function beginning several months after grafting. These findings in a 'preclinical trial' support translation of NPC graft therapy to humans with the objective of reconstituting both a neuronal and glial milieu in the site of spinal cord injury.
我们将人脊髓源性神经前体细胞（NPCs）移植到恒河猴（Macaca mulatta）的颈脊髓损伤部位。在三种药物免疫抑制下，移植物在损伤后至少存活 9 个月，并表达神经元和神经胶质标志物。猴轴突再生到移植物中，并形成突触。数十万个人类轴突从移植物中穿过猴的白质延伸出来，并在远端灰质中形成突触。移植物在 9 个月内逐渐成熟，并在移植后数月开始改善前肢功能。这些在“临床前试验”中的发现支持将 NPC 移植疗法应用于人类，目的是在脊髓损伤部位重建神经元和神经胶质环境。
