灵长类动物脊髓损伤后，内源性神经发生可替代少突胶质细胞和星形胶质细胞。
Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury.
作者信息
Yang Hong, Lu Paul, McKay Heather M, Bernot Tim, Keirstead Hans, Steward Oswald, Gage Fred H, Edgerton V Reggie, Tuszynski Mark H
机构信息
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093-0626, USA.
出版信息
J Neurosci. 2006 Feb 22;26(8):2157-66. doi: 10.1523/JNEUROSCI.4070-05.2005.
Abstract
Neurogenesis has been described in various regions of the CNS throughout life. We examined the extent of natural cell division and replacement from 7 weeks to 7 months after cervical spinal cord injury in four adult rhesus monkeys. Bromodeoxyuridine (BrdU) injections revealed an increase of >80-fold in the number of newly divided cells in the primate spinal cord after injury, with an average of 725,000 BrdU-labeled cells identified per monkey in the immediate injury zone. By 7 months after injury, 15% of these new cells expressed mature markers of oligodendrocytes and 12% expressed mature astrocytic markers. Newly born oligodendrocytes were present in zones of injury-induced demyelination and appeared to ensheath or remyelinate host axons. Thus, cell replacement is an extensive natural compensatory response to injury in the primate spinal cord that contributes to neural repair and is a potential target for therapeutic enhancement.
摘要
神经发生在整个生命过程中都存在于中枢神经系统的各个区域。我们研究了4只成年恒河猴颈脊髓损伤后7周龄至7月龄期间自然细胞分裂和替代的程度。溴脱氧尿苷（BrdU）注射显示，损伤后灵长类脊髓中新分裂细胞的数量增加了80倍以上，在损伤即刻区域，每只猴子平均有725,000个BrdU标记的细胞。损伤后7个月，这些新细胞中有15%表达少突胶质细胞的成熟标志物，12%表达成熟星形胶质细胞标志物。新生少突胶质细胞存在于损伤诱导的脱髓鞘区域，似乎包裹或重新髓鞘化宿主轴突。因此，细胞替代是灵长类脊髓损伤广泛的自然代偿反应，有助于神经修复，是治疗增强的潜在靶点。
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