Akabane S, Kojima S, Igarashi Y, Kawamura M, Matsushima Y, Ito K
Life Sci. 1987 Jan 12;40(2):119-25. doi: 10.1016/0024-3205(87)90350-x.
In order to verify the contribution of right atrial pressure to atrial natriuretic polypeptides (ANP) release, we measured plasma levels of immunoreactive (ir)-ANP when graded rise of right atrial pressure was executed in anesthetized dogs. Increasing right atrial pressure (RAP) from 2.7 +/- 0.6 to 9.0 +/- 0.7 mmHg, plasma levels of ir-ANP in aorta tended to increase by 33% but not significantly (p greater than 0.05). However, when RAP was increased from 9.0 +/- 0.7 to 17.0 +/- 1.1 mmHg, ir-ANP levels in aorta were significantly (p less than 0.05) increased by 132% of control within 5 min from the start of RAP elevation. The RAP elevation produced a sustained increase in plasma levels of ir-ANP. There was a positive correlation between right atrial pressure and plasma levels of ir-ANP. The plasma levels of ir-ANP were similar between aorta and pulmonary artery. These results demonstrate that increasing atrial pressure is closely correlated with ANP release and ANP is not greatly metabolized by pulmonary circulation.
为了验证右心房压力对心房利钠多肽（ANP）释放的作用，我们在麻醉犬身上进行右心房压力分级升高时，测量了免疫反应性（ir）-ANP的血浆水平。将右心房压力（RAP）从2.7±0.6 mmHg升高到9.0±0.7 mmHg时，主动脉中ir-ANP的血浆水平倾向于升高33%，但无显著差异（p>0.05）。然而，当RAP从9.0±0.7 mmHg升高到17.0±1.1 mmHg时，从RAP升高开始5分钟内，主动脉中ir-ANP水平显著（p<0.05）升高，比对照水平升高了132%。RAP升高使ir-ANP的血浆水平持续升高。右心房压力与ir-ANP的血浆水平呈正相关。主动脉和肺动脉之间的ir-ANP血浆水平相似。这些结果表明，心房压力升高与ANP释放密切相关，且ANP在肺循环中未被大量代谢。
