Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.
Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany; REBIRTH Excellence Cluster, Hannover Medical School, Hannover, Germany; National Heart and Lung Institute, Imperial College London, London, UK.
Vascul Pharmacol. 2019 Mar;114:131-138. doi: 10.1016/j.vph.2018.02.008. Epub 2018 Feb 24.
With the advent of empowering sequencing techniques over the past two decades, the scientific community has uncovered many underlying secrets of our genome. Non-coding transcripts covering a staggering 98% of our genome strongly suggest their involvement in diverse cellular pathways. A special class of non-coding RNAs (ncRNAs) namely long non-coding RNAs (lncRNAs) has garnered tremendous attention considering its implications in multiple developmental and pathophysiological processes. Accumulating evidence has established lncRNAs as robust regulators of pathways ranging from embryonic cell development to ultimate diseased phenotype. Here, in particular, we summarize the lncRNAs actively participating in the development of our vasculature and the ones which function as drivers or modulators of fatal vascular diseases.
在过去的二十年中，随着赋权测序技术的出现，科学界已经揭示了我们基因组的许多秘密。覆盖我们基因组惊人的 98%的非编码转录本强烈表明它们参与了各种细胞途径。一类特殊的非编码 RNA（ncRNA），即长非编码 RNA（lncRNA），因其在多种发育和病理生理过程中的作用而引起了极大的关注。越来越多的证据表明，lncRNA 是从胚胎细胞发育到最终疾病表型的途径的强有力调节剂。在这里，我们特别总结了积极参与我们血管系统发育的 lncRNA 以及作为致命血管疾病驱动因子或调节剂的 lncRNA。
