University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
Vascul Pharmacol. 2019 Mar;114:23-30. doi: 10.1016/j.vph.2018.06.004.
In recent years, it has been revealed that majority of the genome is transcribed in a cell- and context-specific manner into a vast array of RNA transcripts that do not encode proteins. Increasing evidence suggests that non-coding RNAs, especially long non-coding RNAs (lncRNAs) are essential regulators of gene expression and other cellular processes, including in the cardiovascular context. In this review, we discuss lncRNAs and their function during endothelial and vascular smooth cell differentiation, function and homeostasis as well as their role in vessel wall injury response and vascular disease pathophysiology. Although our understanding of lncRNAs is still emerging, these examples reveal important insights on how lncRNAs may ultimately be used in clinic as therapeutic targets for cardiovascular disease.
近年来，人们发现大部分基因组在细胞和特定环境中以特定的方式转录成大量不编码蛋白质的 RNA 转录本。越来越多的证据表明，非编码 RNA，尤其是长非编码 RNA（lncRNA），是基因表达和其他细胞过程的重要调节因子，包括心血管环境。在这篇综述中，我们讨论了 lncRNA 及其在血管内皮细胞和血管平滑肌细胞分化、功能和稳态中的作用，以及它们在血管壁损伤反应和血管疾病病理生理学中的作用。尽管我们对 lncRNA 的理解仍在不断发展，但这些例子揭示了 lncRNA 如何最终可能被用作心血管疾病的治疗靶点的重要见解。
