College of Life Science, Northwest A&F University, Shaanxi Yangling, 712100, China.
College of Life Science, Northwest A&F University, Shaanxi Yangling, 712100, China; Zoology Department, Faculty of Science, Tanta University, 31527, Tanta, Egypt.
Biomed Pharmacother. 2018 Apr;100:532-550. doi: 10.1016/j.biopha.2018.02.047. Epub 2018 Feb 23.
Chronic hepatitis is a general designation class of diseases, which results in different degrees of liver necrosis and inflammatory reaction, followed by liver fibrosis, may eventually develop into cirrhosis. However, the molecular pathogenesis of chronic hepatitis is too complex to elucidate. Herbal medicines, featured with multiple targets and compounds, have long displayed therapeutic effect in treating chronic hepatitis, though their molecular mechanisms of contribution remain indistinct. This research utilized the network pharmacology to confirm the molecular pathogenesis of chronic hepatitis through providing a comprehensive analysis of active chemicals, drug targets and pathways' interaction of Sinisan formula for treating chronic hepatitis. The outcomes showed that 80 active ingredients of Sinisan formula interacting with 91 therapeutic proteins were authenticated. Sinisan formula potentially participates in immune modulation, anti-inflammatory and antiviral activities, even has regulating effects on lipid metabolism. These mechanisms directly or indirectly are involved in curing chronic hepatitis by an interaction way. The network pharmacology based analysis demonstrated that Sinisan has multi-scale curative activity in regulating chronic hepatitis related biological processes, which provides a new potential way for modern medicine in the treatment of chronic diseases.
慢性肝炎是一类疾病的总称，可导致不同程度的肝坏死和炎症反应，继而发生肝纤维化，最终可能发展为肝硬化。然而，慢性肝炎的分子发病机制过于复杂，难以阐明。草药以多靶点和化合物为特色，长期以来在治疗慢性肝炎方面显示出疗效，但它们的作用机制仍不明确。本研究利用网络药理学，通过综合分析治疗慢性肝炎的四逆散配方的活性化合物、药物靶点和途径的相互作用，来确定慢性肝炎的分子发病机制。研究结果表明，四逆散配方中鉴定出 80 种与 91 种治疗蛋白相互作用的活性成分。四逆散配方可能参与免疫调节、抗炎和抗病毒作用，甚至对脂质代谢有调节作用。这些机制通过相互作用的方式直接或间接地参与治疗慢性肝炎。基于网络药理学的分析表明，四逆散在调节慢性肝炎相关生物过程方面具有多尺度的治疗活性，为现代医学治疗慢性病提供了新的潜在途径。
