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模拟类癌肿瘤的支气管内膜结核

Endobronchial Tuberculosis Simulating Carcinoid Tumor.

作者信息

Hajjar Waseem, Ahmed Iftikhar, Aljetaily Samiha, Al-Obaidan Tarfah, Hajjar Adnan W

机构信息

Department of Surgery, King Khalid University Hospital, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Medical Student, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

出版信息

J Coll Physicians Surg Pak. 2018 Mar;28(3):S39-S41. doi: 10.29271/jcpsp.2018.03.S39.

Abstract

Diagnosing endobronchial tuberculosis (EBTB) can be difficult due to the lack of specific signs and symptoms that differentiate it from other respiratory diseases, such as lung tumors. We hereby report a case of a very rare presentation of tuberculosis (TB) in a patient who presented with a dry cough and significant weight loss for 3 months. Chest X-ray and CT scan of the chest showed partial atelectasis and a segmental collapse of the right upper lobe and tumor-like arising from its bronchus along with a large right para-tracheal mediastinal lymphadenopathy, mimicking a metastatic (N2) disease. Fiber-optic bronchoscopy revealed a fleshy, highly vascularized mass occluding the right upper lobe bronchus, and thus the initial diagnosis of carcinoid tumor was made. Mediastinoscopy and biopsy of these mediastinal lymph nodes showed caseating chronic granulomatous inflammation consistent with TB, which changed the diagnosis to EBTB. The patient was treated with first-line anti-tuberculous drugs that led to a full resolution in terms of symptoms, radiological findings and complete disappearance of the endobronchial mass by bronchoscopy. To the best of authors' knowledge, there are no other similar cases in presentation and management in the literature.

摘要

由于缺乏可将支气管内膜结核(EBTB)与其他呼吸道疾病(如肺部肿瘤)区分开来的特异性体征和症状,诊断支气管内膜结核可能会很困难。我们在此报告一例非常罕见的结核病(TB)病例,该患者出现干咳并伴有3个月的显著体重减轻。胸部X光和胸部CT扫描显示右肺上叶部分肺不张和节段性萎陷,以及支气管处类似肿瘤的病变,并伴有右侧气管旁纵隔淋巴结肿大,酷似转移性(N2)疾病。纤维支气管镜检查发现一个肉质、血管丰富的肿块阻塞了右肺上叶支气管,因此初步诊断为类癌肿瘤。纵隔镜检查和这些纵隔淋巴结活检显示为干酪样慢性肉芽肿性炎症,符合结核病,从而将诊断改为支气管内膜结核。该患者接受了一线抗结核药物治疗,症状、影像学表现完全缓解,支气管镜检查显示支气管内肿块完全消失。据作者所知,文献中在表现和治疗方面没有其他类似病例。

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