比较面罩和咬嘴接口在多次呼吸清洗测量中的应用。
Comparison of facemask and mouthpiece interfaces for multiple breath washout measurements.
机构信息
Department of Respiratory Medicine, The Children's Hospital at Westmead, Westmead, Australia; Discipline of Paediatrics and Child Health, University of Sydney, Westmead, Australia.
Respiratory, Critical Care & Anaesthesia section, UCL, Institute of Child Health, London, United Kingdom.
出版信息
J Cyst Fibros. 2018 Jul;17(4):511-517. doi: 10.1016/j.jcf.2018.01.003. Epub 2018 Mar 2.
BACKGROUND
Different interfaces (mouthpiece/nose clip vs. facemask) are used during multiple breath washout (MBW) tests in young children.
METHODS
We investigated the effect of interface choice and breathing modalities on MBW outcomes in healthy adults and preschool children.
RESULTS
In adults (n = 26) facemask breathing significantly increased LCI, compared to mouthpiece use (mean difference (95% CI) 0.4 (0.2; 0.6)), with results generalizable across sites and different equipment. Exclusively nasal breathing within the facemask increased LCI, as compared to oral breathing. In preschoolers (2-6 years, n = 46), no significant inter-test difference was observed across interfaces for LCI or FRC. Feasibility and breathing stability were significantly greater with facemask (incorporating dead space volume minimization), vs. mouthpiece. This was more pronounced in subjects <4 years of age.
CONCLUSION
Both nasal vs. oral breathing and mouthpiece vs. facemask affect LCI measurements in adults. This effect was minimal in preschool children, where switching between interfaces is most likely to occur.
背景
在多次呼吸冲洗（MBW）测试中，不同的接口（咬嘴/鼻夹与面罩）用于幼儿。
方法
我们研究了接口选择和呼吸方式对健康成年人和学龄前儿童 MBW 结果的影响。
结果
在成年人（n=26）中，与使用咬嘴相比，面罩呼吸显著增加了 LCI（平均差异（95%CI）0.4（0.2；0.6）），结果在不同的地点和不同的设备之间具有可推广性。与口腔呼吸相比，面罩内仅用鼻腔呼吸会增加 LCI。在学龄前儿童（2-6 岁，n=46）中，LCI 或 FRC 在内窥镜之间没有明显的测试间差异。面罩（包含死腔体积最小化）的可行性和呼吸稳定性显著大于咬嘴。对于<4 岁的儿童，这种情况更为明显。
结论
在成年人中，无论是鼻腔呼吸还是口腔呼吸，还是咬嘴与面罩的选择，都会影响 LCI 的测量。对于最有可能在接口之间切换的学龄前儿童，这种影响最小。
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