单端孢霉烯族霉菌毒素的代谢转化：3-乙酰脱氧雪腐镰刀菌烯醇向镰刀菌烯酮-X的生物转化
Metabolic conversions of trichothecene mycotoxins: biotransformation of 3-acetyldeoxynivalenol into fusarenon-X.
作者信息
Baldwin N C, Bycroft B W, Dewick P M, Gilbert J
出版信息
Z Naturforsch C J Biosci. 1986 Sep-Oct;41(9-10):845-50.
PMID:2948328
Abstract
The trichothecene mycotoxin 3-acetyldeoxynivalenol was transformed by cultures of the diacetoxyscirpenol producer Fusarium sp. strain C37410-90 into four compounds, identified as deoxynivalenol, 15-acetyldeoxynivalenol, 3,15-diacetyldeoxynivalenol and fusarenon-X. The major transformations are the result of specific esterification and de-esterification processes, but the production of fusarenon-X involves in addition a novel 4 beta-hydroxylation of the trichothecene ring system itself.
摘要
单端孢霉烯族霉菌毒素3-乙酰脱氧雪腐镰刀菌烯醇被二醋酸镳草镰刀菌烯醇产生菌镰刀菌属菌株C37410-90的培养物转化为四种化合物，鉴定为脱氧雪腐镰刀菌烯醇、15-乙酰脱氧雪腐镰刀菌烯醇、3,15-二乙酰脱氧雪腐镰刀菌烯醇和镰刀菌烯酮-X。主要转化是特定酯化和脱酯化过程的结果，但镰刀菌烯酮-X的产生还涉及单端孢霉烯环系统本身一种新的4β-羟基化反应。
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