通过生物转化对霉菌毒素进行解毒
Detoxification of Mycotoxins through Biotransformation.
作者信息
Li Peng, Su Ruixue, Yin Ruya, Lai Daowan, Wang Mingan, Liu Yang, Zhou Ligang
机构信息
Department of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, China.
Department of Applied Chemistry, College of Sciences, China Agricultural University, Beijing 100193, China.
出版信息
Toxins (Basel). 2020 Feb 14;12(2):121. doi: 10.3390/toxins12020121.
Mycotoxins are toxic fungal secondary metabolites that pose a major threat to the safety of food and feed. Mycotoxins are usually converted into less toxic or non-toxic metabolites through biotransformation that are often made by living organisms as well as the isolated enzymes. The conversions mainly include hydroxylation, oxidation, hydrogenation, de-epoxidation, methylation, glycosylation and glucuronidation, esterification, hydrolysis, sulfation, demethylation and deamination. Biotransformations of some notorious mycotoxins such as alfatoxins, alternariol, citrinin, fomannoxin, ochratoxins, patulin, trichothecenes and zearalenone analogues are reviewed in detail. The recent development and applications of mycotoxins detoxification through biotransformation are also discussed.
霉菌毒素是有毒的真菌次生代谢产物，对食品和饲料安全构成重大威胁。霉菌毒素通常通过生物转化转化为毒性较低或无毒的代谢产物，生物转化通常由生物体以及分离出的酶来完成。这些转化主要包括羟基化、氧化、氢化、脱环氧化、甲基化、糖基化和葡萄糖醛酸化、酯化、水解、硫酸化、去甲基化和脱氨基作用。本文详细综述了一些臭名昭著的霉菌毒素，如黄曲霉毒素、链格孢酚、桔霉素、腐马霉素、赭曲霉毒素、展青霉素、单端孢霉烯族毒素和玉米赤霉烯酮类似物的生物转化。还讨论了通过生物转化进行霉菌毒素解毒的最新进展和应用。
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