Legras B, Cottencin M, Grangaud R
Ann Nutr Aliment. 1979;33(3):395-404.
When Wistar and Sprague-Dawley rats fed from weaning on a vitamin A and provitamin A deficient diet are supplemented with retinoic acid, they mature into adults whose general physical conditions and weight are comparable with those of retinol supplemented animals. However, the adrenal cortex, testes and ovaries delta 5-3 beta hydroxysteroid deshydrogenases-delta 5-delta 4-3-oxosteroide isomerases are in all cases strongly decreased compared with those of retinol supplemented animals. These results are reproducible only if the mothers' reserves in vitamin A are about 50 gamma/g of hepatic tissue and if the animals are weaned between the 19th and 21st day. These results obtained under these strictly defined conditions demonstrate the importance of the "biochemical lesion" which causes steroidogenesis perturbations induced by the vitamin A deficiency. The experimental data are discussed in the light of the recent findings concerning the direct role of the vitamin A in the transglycosylation reactions (Luigi M. de Luca, Vitamins and Hormones, 1977, 35, 1-57).
从断奶开始就以缺乏维生素A和维生素A原的饮食喂养的Wistar大鼠和Sprague-Dawley大鼠，若补充视黄酸，它们会发育成熟为成年大鼠，其总体身体状况和体重与补充视黄醇的动物相当。然而，与补充视黄醇的动物相比，它们的肾上腺皮质、睾丸和卵巢中的δ5-3β-羟类固醇脱氢酶-δ5-δ4-3-氧代类固醇异构酶在所有情况下均显著降低。只有当母体肝脏组织中的维生素A储备约为50γ/g，且动物在第19至21天断奶时，这些结果才具有可重复性。在这些严格定义的条件下获得的这些结果证明了导致维生素A缺乏引起的类固醇生成紊乱的“生化损伤”的重要性。根据最近关于维生素A在转糖基化反应中的直接作用的研究结果（路易吉·M·德·卢卡，《维生素与激素》，1977年，35卷，1 - 57页）对实验数据进行了讨论。
