血清蛋白复合物水平升高与 2 型糖尿病有关。
Increased Levels of Serum Protein Complexes Are Associated with Type 2 Diabetes.
机构信息
Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing 100005, PR China.
Department of Clinical Laboratory, Heze Municipal Hospital, Shandong 274031, PR China.
出版信息
Int J Med Sci. 2018 Jan 1;15(3):210-216. doi: 10.7150/ijms.22517. eCollection 2018.
: To screen novel biomarkers in the levels of protein complexes for type 2 diabetes mellitus (T2DM). : Serum immunoinflammation-related protein complexes (IIRPCs) and diabetes-related protein complexes (DRPCs) in 1537 serum samples including 504 healthy controls, 320 patients with prediabetes, and 713 patients with T2DM were analyzed using an optimized native polyacrylamide gel electrophoresis (native-PAGE). : Seven patterns of serum IIRPCs and four patterns of serum DRPCs were observed in the study population, respectively. Significant increase in the levels of serum IIRPCs in T2DM was detected relative to healthy controls. Change trends of serum DRPCs are as below: patients with T2DM>patients with prediabetes> healthy controls. : Our findings suggest that increased levels of serum IIRPCs and DRPCs were associated with T2DM.
: 目的：筛选 2 型糖尿病（T2DM）患者血清中蛋白质复合物相关的新型生物标志物。 : 采用优化的天然聚丙烯酰胺凝胶电泳（native-PAGE）方法，对包括 504 例健康对照者、320 例糖尿病前期患者和 713 例 T2DM 患者在内的 1537 例血清样本中的血清免疫炎症相关蛋白复合物（IIRPCs）和糖尿病相关蛋白复合物（DRPCs）进行分析。 : 在研究人群中分别观察到 7 种血清 IIRPC 模式和 4 种血清 DRPC 模式。与健康对照组相比，T2DM 患者血清 IIRPCs 水平显著升高。血清 DRPCs 的变化趋势如下：T2DM 患者>糖尿病前期患者>健康对照组。 : 本研究结果提示，血清 IIRPCs 和 DRPCs 水平的升高与 T2DM 相关。
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