血清脂联素和维生素 D 在糖尿病前期和糖尿病中的作用。
Role of Serum Adiponectin and Vitamin D in Prediabetes and Diabetes Mellitus.
机构信息
Department of Biochemistry, ICARE Institute of Medical Sciences and Research, Haldia, India; Department of Biochemistry, Institute of Post Graduate Medical Education and Research, Kolkata, India.
Department of Biochemistry, ICARE Institute of Medical Sciences and Research, Haldia, India; Department of Biochemistry, Institute of Post Graduate Medical Education and Research, Kolkata, India.
出版信息
Can J Diabetes. 2017 Jun;41(3):259-265. doi: 10.1016/j.jcjd.2016.10.006. Epub 2017 Feb 22.
OBJECTIVES
The roles of deficient or deranged insulin, adiponectin and 25 hydroxy vitamin D (25[OH]D) levels regulating food intake, energy metabolism, glucose and lipid metabolism and body weight have been reported in the pathogenesis of prediabetes and type 2 diabetes mellitus. However, their congruity in the etiology of diabetes mellitus is unknown. Thus, the aim of the study was to investigate the roles of these parameters together and to establish their interrelationship in patients with prediabetes and diabetes.
METHODS
The preliminary cross-sectional study included 77 persons with type 2 diabetes who were matched for age, sex and body mass index (BMI); 73 persons with prediabetes; and 52 healthy control subjects. Fasting serum levels of adiponectin, insulin and 25(OH)D were measured by commercially available immune assay kits, and routine biochemical parameters were analyzed in all study groups.
RESULTS
The results show statistically significant lower levels of serum adiponectin and serum 25(OH)D and higher serum insulin levels in persons with prediabetes or type 2 diabetes with respect to controls. The changes in the serum adiponectin or serum 25(OH)D in persons with prediabetes and type 2 diabetes were found to be inversely correlated with the serum levels of insulin. Moreover, multiple linear regression analysis, with 25(OH)D, insulin and homeostatic model assessment-insulin resistance (HOMA-IR) as the variables, revealed that serum adiponectin levels might be an independent risk factor for the progression of prediabetes and type 2 diabetes in subjects.
CONCLUSIONS
The association of these hormones might act as a significant predictor of progression of prediabetes to type 2 diabetes. Decreased serum adiponectin levels might be an independent risk factor for progression to prediabetes and type 2 diabetes, which may help in developing experimental models of the disease or in identifying biomarkers or disease-modifying drugs.
目的
胰岛素、脂联素和 25 羟维生素 D（25[OH]D）水平不足或失调在调节食欲、能量代谢、葡萄糖和脂质代谢以及体重方面的作用已在糖尿病前期和 2 型糖尿病的发病机制中得到报道。然而，它们在糖尿病发病机制中的一致性尚不清楚。因此，本研究的目的是研究这些参数的作用，并确定它们在糖尿病前期和糖尿病患者中的相互关系。
方法
初步的横断面研究包括 77 例 2 型糖尿病患者，这些患者在年龄、性别和体重指数（BMI）方面与对照组相匹配；73 例糖尿病前期患者；和 52 例健康对照组。使用商业可得的免疫测定试剂盒测量空腹血清脂联素、胰岛素和 25（OH）D 水平，所有研究组均分析常规生化参数。
结果
结果显示，与对照组相比，糖尿病前期或 2 型糖尿病患者的血清脂联素和血清 25（OH）D 水平显著降低，血清胰岛素水平升高。在糖尿病前期和 2 型糖尿病患者中，血清脂联素或血清 25（OH）D 的变化与血清胰岛素水平呈负相关。此外，多元线性回归分析显示，以 25（OH）D、胰岛素和稳态模型评估-胰岛素抵抗（HOMA-IR）为变量，血清脂联素水平可能是这些患者糖尿病前期和 2 型糖尿病进展的独立危险因素。
结论
这些激素的相关性可能是糖尿病前期进展为 2 型糖尿病的重要预测指标。血清脂联素水平降低可能是糖尿病前期和 2 型糖尿病进展的独立危险因素，这可能有助于开发疾病的实验模型或识别生物标志物或疾病修饰药物。
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