Zeiderman Matthew R, Kelishadi Shahrooz Sean, Tutela John Paul, Rao Arun, Chowdhry Saeed, Brooks Ronald M, Wilhelmi Bradon J
Division of Plastic & Reconstructive Surgery, Department of Surgery, University of Louisville School of Medicine, Louisville, Ky.
SSK Plastic and Reconstructive Surgery, Newport Beach, Calif.
Eplasty. 2018 Feb 7;18:e6. eCollection 2018.
Minimally invasive cosmetic procedures are the most commonly performed aesthetic techniques by plastic surgeons. Patients are interested in a pain-free experience. Surgeons desire patient satisfaction and time-efficient utilization of office staff and resources. Clinical evidence exists for use of vapocoolant technology to reduce pain associated with intravenous cannulation in the pediatric population and in hemodialysis patients. Applying vapocoolant technology to facial rejuvenation is a novel approach to decrease pain associated with neurotoxin or filler injection. A randomized, prospective study was conducted, testing 15 subjects receiving filler injections and another 15 patients receiving neurotoxin injections using a split-face model. The vapocoolant spray used was composed of a 95:5 ratio of 1,1,1,3,3-pentafluoropropane and 1,1,1,2-tetrafluoroethane. Within each group, individual patients randomly received injection (filler or neurotoxin) alone versus injection (filler or neurotoxin) plus vapocoolant on an equivalent half of his or her face. An independent examiner recorded from each patient on a scale of 1 to 10 perceived pain for injection alone versus injection plus vapocoolant spray. Results were calculated as a percentage change of pain scores experienced after injection for each person between the control (nonvapocoolant) and treatment (vapocoolant) sides of the face. Vapocoolant spray at the time of cosmetic facial injections leads to a 59% decrease in perceived pain score with neurotoxin injections (range, 0%-100% change) and 64% decrease in perceived pain score with filler injections (range, 0%-100% change). These results were statistically significant with < .05. Vapocoolant spray reduces pain associated with facial rejuvenation procedures.
微创美容手术是整形外科医生最常施行的美容技术。患者追求无痛体验。外科医生期望患者满意，同时高效利用办公室工作人员和资源。有临床证据表明，在儿科患者和血液透析患者中，使用汽化冷却技术可减轻静脉插管相关的疼痛。将汽化冷却技术应用于面部年轻化是一种减少神经毒素或填充剂注射相关疼痛的新方法。进行了一项随机前瞻性研究，采用半脸模型对15名接受填充剂注射的受试者和另外15名接受神经毒素注射的患者进行测试。所使用的汽化冷却喷雾由1,1,1,3,3 - 五氟丙烷和1,1,1,2 - 四氟乙烷按95:5的比例组成。在每组中，个体患者在其脸部的等效半侧随机接受单独注射（填充剂或神经毒素）与注射（填充剂或神经毒素）加汽化冷却剂。一名独立检查人员记录每位患者单独注射与注射加汽化冷却喷雾时从1到10的疼痛感知评分。结果以每个人面部对照（非汽化冷却剂）侧和治疗（汽化冷却剂）侧注射后疼痛评分的百分比变化来计算。面部美容注射时使用汽化冷却喷雾可使神经毒素注射的疼痛感知评分降低59%（变化范围为0% - 100%），填充剂注射的疼痛感知评分降低64%（变化范围为0% - 100%）。这些结果具有统计学意义，P <.05。汽化冷却喷雾可减轻面部年轻化手术相关的疼痛。
