Govindsamy Annelene, Naidoo Strinivasen, Cerf Marlon E
Discipline of Pharmaceutical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Biomedical Research and Innovation Platform, South African Medical Research Council, Cape Town, South Africa.
J Nutr Metab. 2018 Feb 1;2018:8547976. doi: 10.1155/2018/8547976. eCollection 2018.
Programming with an insult or stimulus during critical developmental life stages shapes metabolic disease through divergent mechanisms. Cardiovascular disease increasingly contributes to global morbidity and mortality, and the heart as an insulin-sensitive organ may become insulin resistant, which manifests as micro- and/or macrovascular complications due to diabetic complications. Cardiogenesis is a sequential process during which the heart develops into a mature organ and is regulated by several cardiac-specific transcription factors. Disrupted cardiac insulin signalling contributes to cardiac insulin resistance. Intrauterine under- or overnutrition alters offspring cardiac structure and function, notably cardiac hypertrophy, systolic and diastolic dysfunction, and hypertension that precede the onset of cardiovascular disease. Optimal intrauterine nutrition and oxygen saturation are required for normal cardiac development in offspring and the maintenance of their cardiovascular physiology.
在关键的发育生命阶段受到侮辱或刺激进行编程，会通过不同机制引发代谢性疾病。心血管疾病对全球发病率和死亡率的影响日益增加，心脏作为一个对胰岛素敏感的器官可能会出现胰岛素抵抗，这会表现为糖尿病并发症导致的微血管和/或大血管并发症。心脏发生是一个连续的过程，在此过程中，心脏发育成为一个成熟的器官，并受到多种心脏特异性转录因子的调控。心脏胰岛素信号传导中断会导致心脏胰岛素抵抗。子宫内营养不足或营养过剩会改变后代的心脏结构和功能，特别是在心血管疾病发作之前出现的心脏肥大、收缩和舒张功能障碍以及高血压。后代正常的心脏发育及其心血管生理功能的维持需要最佳的子宫内营养和氧饱和度。
