Cunha da Cruz Juliana, Machado de Castro Aline, Camporese Sérvulo Eliana Flávia
1Escola de Química, Universidade Federal do Rio de Janeiro, 2030, Centro de Tecnologia, Ilha do Fundão, Rio de Janeiro, RJ 21949-909 Brazil.
2Divisão de Biotecnologia, Centro de Pesquisa e Desenvolvimento, PETROBRAS, Av. Horácio Macedo, 950. Ilha do Fundão, Rio de Janeiro, RJ 21941-915 Brazil.
3 Biotech. 2018 Mar;8(3):138. doi: 10.1007/s13205-018-1151-0. Epub 2018 Feb 16.
The itaconic acid (IA) world market is expected to exceed 216 million of dollars by 2020 as a result of an increasing demand for bio-based chemicals. The potential of this organic acid produced by fermentation mainly with filamentous fungi relies on the vast industrial applications of polymers derived from it. The applications may be as a superabsorbent polymer for personal care or agriculture, unsaturated polyester resin for the transportation industry, poly(methyl methacrylate) for electronic devices, among many others. However, the existence of other substitutes and the high production cost limit the current IA market. IA manufacturing is done mainly in China and other Asia-Pacific countries. Higher economic feasibility and production worldwide may be achieved with the use of low-cost feedstock of local origin and with the development of applications targeted to specific local markets. Moreover, research on the biological pathway for IA synthesis and the effect of medium composition are important for amplifying the knowledge about the production of that biochemical with great market potential.
由于对生物基化学品的需求不断增加，预计到2020年，衣康酸（IA）的世界市场将超过2.16亿美元。这种主要由丝状真菌发酵产生的有机酸的潜力，依赖于由其衍生的聚合物在广泛工业应用中的表现。这些应用可以是用于个人护理或农业的高吸水性聚合物、用于运输行业的不饱和聚酯树脂、用于电子设备的聚甲基丙烯酸甲酯等等。然而，其他替代品的存在以及高生产成本限制了当前的衣康酸市场。衣康酸的生产主要在中国和其他亚太国家进行。使用本地低成本原料并开发针对特定本地市场的应用，可能会在全球范围内实现更高的经济可行性和产量。此外，对衣康酸合成的生物途径以及培养基成分的影响进行研究，对于扩大对这种具有巨大市场潜力的生化产品生产的认识非常重要。
