Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
J Diabetes Res. 2018 Feb 1;2018:4783093. doi: 10.1155/2018/4783093. eCollection 2018.
Thyroid dysfunction is known to exaggerate the coronary heart disease (CHD) risk associated with type 2 diabetes mellitus (T2DM) among whites. The effect is yet to be studied among African populations.
This is a cross-sectional study involving 780 T2DM patients enrolled in a diabetes clinic in Kumasi, Ghana. CHD risk was estimated using the Framingham and UKPDS risk scores. Risks were categorised as low (<10%), intermediate (10-19%), and high (≥20%). Associations between metabolic risk factors, thyroid dysfunction, and CHD risk were measured using Spearman's partial correlation analysis while controlling for age and gender. Differences were considered statistically significant at < 0.05.
780 T2DM patients (57.7% females), mean ± SD age of 57.4 ± 9.4 was analysed. The median (IQR) 10-year CHD score estimated using the Framingham and UKPDS risk engines for males and females was 12 (8-20), 9.4 (5.7-13.4), < 0.0001 and 3 (1-6), 5.8 (3.4-9.6), < 0.0001, respectively. Positive correlation was found between CHD risk and HbA1c, total cholesterol, low-density lipoprotein cholesterol, systolic blood pressure, and thyroid stimulating hormone.
The presence of thyroid dysfunction significantly increased the CHD risk associated with T2DM patients in Ghana.
已知甲状腺功能障碍会使 2 型糖尿病（T2DM）患者的冠心病（CHD）风险在白人中加剧。但这种影响尚未在非洲人群中进行研究。
这是一项横断面研究，涉及加纳库马西糖尿病诊所的 780 名 T2DM 患者。使用 Framingham 和 UKPDS 风险评分估计 CHD 风险。风险分为低（<10%）、中（10-19%）和高（≥20%）。使用 Spearman 部分相关分析控制年龄和性别后，测量代谢风险因素、甲状腺功能障碍与 CHD 风险之间的相关性。差异具有统计学意义，P 值 < 0.05。
分析了 780 名 T2DM 患者（57.7%为女性），平均年龄为 57.4 ± 9.4 岁。Framingham 和 UKPDS 风险引擎估计的男性和女性的 10 年 CHD 评分中位数（IQR）分别为 12（8-20）、9.4（5.7-13.4），P < 0.0001和 3（1-6）、5.8（3.4-9.6），P < 0.0001。CHD 风险与 HbA1c、总胆固醇、低密度脂蛋白胆固醇、收缩压和促甲状腺激素呈正相关。
甲状腺功能障碍的存在显著增加了加纳 T2DM 患者的 CHD 风险。
