The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana.

BACKGROUND

Thyroid dysfunction is known to exaggerate the coronary heart disease (CHD) risk associated with type 2 diabetes mellitus (T2DM) among whites. The effect is yet to be studied among African populations.

METHODS

This is a cross-sectional study involving 780 T2DM patients enrolled in a diabetes clinic in Kumasi, Ghana. CHD risk was estimated using the Framingham and UKPDS risk scores. Risks were categorised as low (<10%), intermediate (10-19%), and high (≥20%). Associations between metabolic risk factors, thyroid dysfunction, and CHD risk were measured using Spearman's partial correlation analysis while controlling for age and gender. Differences were considered statistically significant at < 0.05.

RESULTS

780 T2DM patients (57.7% females), mean ± SD age of 57.4 ± 9.4 was analysed. The median (IQR) 10-year CHD score estimated using the Framingham and UKPDS risk engines for males and females was 12 (8-20), 9.4 (5.7-13.4), < 0.0001 and 3 (1-6), 5.8 (3.4-9.6), < 0.0001, respectively. Positive correlation was found between CHD risk and HbA1c, total cholesterol, low-density lipoprotein cholesterol, systolic blood pressure, and thyroid stimulating hormone.

CONCLUSION

The presence of thyroid dysfunction significantly increased the CHD risk associated with T2DM patients in Ghana.