用于拆分外消旋氨基酸的热响应性可回收聚合物抑制剂。
Thermo-responsive recoverable polymeric inhibitors for the resolution of racemic amino acids.
作者信息
Ye Xichong, Zhang Jie, Cui Jiaxi, Wan Xinhua
机构信息
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
出版信息
Chem Commun (Camb). 2018 Mar 13;54(22):2785-2787. doi: 10.1039/c8cc00333e.
Novel polymeric inhibitors with lower critical solution temperatures in water were prepared and used to mediate the crystallization of racemic asparagine monohydrate, leading to chiral separation with 88.6 ee%. They could be recollected by simply elevating the temperature with a high yield of around 95% and reused without compromising the stereoselectivity and stability.
制备了在水中具有较低临界溶液温度的新型聚合物抑制剂，并将其用于介导外消旋一水合天冬酰胺的结晶，从而实现了88.6%对映体过量的手性拆分。通过简单地升高温度即可将它们回收，回收率高达95%左右，且回收后可重复使用，而不会影响其立体选择性和稳定性。
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