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2004 年至 2014 年间,儿童注意缺陷多动障碍表型是否变得更为常见?来自瑞典一般人群样本的 10 年趋势。

Has the attention deficit hyperactivity disorder phenotype become more common in children between 2004 and 2014? Trends over 10 years from a Swedish general population sample.

机构信息

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, Sweden.

出版信息

J Child Psychol Psychiatry. 2018 Aug;59(8):863-871. doi: 10.1111/jcpp.12882. Epub 2018 Feb 27.

Abstract

BACKGROUND

Studies have reported increases in clinically diagnosed and treated attention deficit hyperactivity disorder (ADHD) during the last decade, but it is unclear if this reflects an increase in the underlying ADHD phenotype. We aimed to clarify if there has been an increase in the prevalence of ADHD-like traits in the general population from 2004 to 2014.

METHOD

Data were collected from 9-year-old twins (19,271), participating in the population-based Child and Adolescent Twin Study in Sweden between 2004 and 2014. We assessed lifetime ADHD symptoms using the Autism-Tics, ADHD and other Comorbidities inventory. Research proxies for diagnostic-level ADHD and subthreshold ADHD were derived from this scale. We modeled the lifetime prevalence of diagnostic-level and subthreshold ADHD with logistic regression, and assessed mean ADHD scores each year with linear regression. Lifetime prevalence of clinically diagnosed ADHD was retrieved from the National Patient Register and modeled with logistic regression.

RESULTS

The prevalence of diagnostic-level ADHD based on parent ratings did not differ significantly over time from 2004 to 2014 (OR 1.37; 95% CI: 0.77-2.45; p-value .233). Both subthreshold ADHD and mean ADHD scores increased significantly over time (both p-values <.001). Clinically diagnosed ADHD increased more than fivefold from 2004 to 2014 (OR 5.27, 95% CI: 1.85-14.96).

CONCLUSIONS

We found no evidence of an increase in ADHD-like traits at the extreme end of the distribution from 2004 to 2014, but small increases in normal and subthreshold variations of ADHD-like traits were observed. This suggests that the increased rates of clinically diagnosed ADHD might reflect changes in diagnostic and treatment practices of ADHD, administrative changes in reporting diagnoses, greater awareness of ADHD, better access to healthcare, or current overdiagnosis, rather than an increase in the ADHD phenotype.

摘要

背景

研究报告称,在过去十年中,临床上诊断和治疗的注意力缺陷多动障碍(ADHD)有所增加,但尚不清楚这是否反映了潜在 ADHD 表型的增加。我们旨在明确 2004 年至 2014 年期间一般人群中是否存在 ADHD 样特征的患病率增加。

方法

数据来自于参加瑞典基于人群的儿童和青少年双胞胎研究的 9 岁双胞胎(19271 人),该研究于 2004 年至 2014 年进行。我们使用自闭症-抽搐、ADHD 和其他共病清单评估终生 ADHD 症状。该量表衍生出研究代理的 ADHD 诊断水平和亚阈值 ADHD。我们使用逻辑回归模型来预测诊断水平和亚阈值 ADHD 的终生患病率,并使用线性回归来评估每年的平均 ADHD 评分。从国家患者登记处检索临床诊断的 ADHD 终生患病率,并使用逻辑回归模型进行预测。

结果

基于父母评定的 ADHD 诊断水平的患病率在 2004 年至 2014 年期间没有显著变化(OR 1.37;95%CI:0.77-2.45;p 值.233)。亚阈值 ADHD 和平均 ADHD 评分均随时间显著增加(均 p 值<.001)。从 2004 年至 2014 年,临床诊断的 ADHD 增加了五倍以上(OR 5.27,95%CI:1.85-14.96)。

结论

我们没有发现 2004 年至 2014 年间 ADHD 样特征在分布极端处增加的证据,但观察到 ADHD 样特征的正常和亚阈值变化略有增加。这表明临床上诊断的 ADHD 增加可能反映了 ADHD 诊断和治疗实践的变化、诊断报告的行政变化、对 ADHD 的认识提高、获得医疗保健的机会增加,或者当前的过度诊断,而不是 ADHD 表型的增加。

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