Department of Kinesiology, Mississippi State University, Mississippi State, MS, USA.
School of Nutrition and Health Promotion, Program of Exercise Science and Health Promotion, Arizona State University, Phoenix, AZ, USA.
J Intellect Disabil Res. 2018 Apr;62(4):339-348. doi: 10.1111/jir.12474. Epub 2018 Feb 27.
High prevalence of obesity and features of obstructive sleep apnea (OSA) are major health issues in individuals with Down syndrome (DS), and both may also affect adversely on their daily activities. Further, lower levels of physical work capacity (PWC) have been reported in this population compared to their peers with intellectual disabilities. However, no study examines the relationships between obesity and sleep problems with PWC in individuals with DS. Thus, this study investigated the influence of body mass index (BMI) and different types of sleep problems on PWC in adolescents and young adults with DS (14-31 years).
The incremental treadmill walking trial was used to assess PWC.
The negative associations were indicated between BMI and walking steps (p = .03) as well as features with OSA and walking steps (p = .04). Thus, BMI and OSA were included in the regression analysis to estimate the walking steps achieved during walking trials. In addition, Bland-Altman plots demonstrated no overestimation and underestimation of variability in the difference between actual and estimated walking steps developed by using BMI and OSA.
Obesity and sleep problem are potentially detrimental to walking performance (i.e., fewer walking steps) in individuals with DS. Thus, individuals with DS may adopt a slow walk speed due to the increased balance deficits and physical fatigue that result from obesity and sleep fragmentation, respectively. Exercise interventions, which have the potential to reduce obesity and OSA, are recommended to improve the accomplishment of PWC in individuals with DS.
肥胖症和阻塞性睡眠呼吸暂停（OSA）的特征是唐氏综合征（DS）患者的主要健康问题，两者也可能对他们的日常活动产生不利影响。此外，与智力障碍的同龄人相比，该人群的体力工作能力（PWC）水平较低。然而，尚无研究检查 DS 患者的肥胖症和睡眠问题与 PWC 之间的关系。因此，本研究调查了青少年和年轻的 DS 患者（14-31 岁）的 BMI 和不同类型的睡眠问题对 PWC 的影响。
使用增量跑步机步行试验评估 PWC。
BMI 与步行步数呈负相关（p=0.03），OSA 的特征与步行步数呈负相关（p=0.04）。因此，将 BMI 和 OSA 纳入回归分析，以估计步行试验中行走的步数。此外，Bland-Altman 图表明，使用 BMI 和 OSA 开发的实际和估计行走步数之间差异的变异性没有高估和低估。
肥胖症和睡眠问题可能会对 DS 患者的步行表现（即行走步数减少）产生不利影响。因此，由于肥胖和睡眠碎片化分别导致平衡缺陷和身体疲劳，DS 患者可能会采用较慢的步行速度。建议进行运动干预，以减少肥胖症和 OSA，从而提高 DS 患者的 PWC 完成能力。
