负载丁香酚的静电纺聚腈纳米纤维垫对白色念珠菌的抗真菌活性
Antifungal Activity of Eugenol Loaded Electrospun PAN Nanofiber Mats Against Candida Albicans.
作者信息
Semnani Kourosh, Shams-Ghahfarokhi Masoomeh, Afrashi Mehran, Fakhrali Aref, Semnani Dariush
机构信息
Department of Mycology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14115-331, Iran.
Department of Textile Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
出版信息
Curr Drug Deliv. 2018;15(6):860-866. doi: 10.2174/1567201815666180226120436.
BACKGROUND
Eugenol, as the major phenolic component of clove essential oil due to its desired properties in medical field, was loaded into polyacrylonitrile (PAN) nanofibers with various percentages.
OBJECTIVE
Our main purpose in this study was to determine the in vitro antifungal activity of eugenol loaded on PAN nanofibers against Candida albicans as the most common causative agent for candidiasis.
METHOD
Also, the surface morphology and the mechanical properties of nanofibers were studied by scanning electron microscope (SEM) and a tensile tester, respectively. The average diameters of nanofibers in pure PAN nanofibers were found to be 127 nm.
RESULTS
The results showed that the average diameter of nanofibers after increasing the eugenol ratio (from 127 to 179-218 nm) was increased. Drug release profile of the samples was gradual and was completed after 150 hours.
CONCLUSION
According to the results, these nanofiber mats loaded with eugenol can be used for treating cutaneous mucocutaneous candidiasis in high risk patients as a coating on a fabric substrate or temporary wound dressing.
背景
丁香酚作为丁香精油的主要酚类成分，因其在医学领域的优良特性，被以不同比例载入聚丙烯腈（PAN）纳米纤维中。
目的
本研究的主要目的是测定载入PAN纳米纤维的丁香酚对白色念珠菌（念珠菌病最常见的病原体）的体外抗真菌活性。
方法
此外，分别通过扫描电子显微镜（SEM）和拉伸试验机研究了纳米纤维的表面形态和力学性能。发现纯PAN纳米纤维的平均直径为127纳米。
结果
结果表明，丁香酚比例增加后纳米纤维的平均直径增大（从127纳米增至179 - 218纳米）。样品的药物释放曲线是渐进的，150小时后释放完毕。
结论
根据结果，这些载入丁香酚的纳米纤维垫可作为织物基质上的涂层或临时伤口敷料，用于治疗高危患者的皮肤黏膜念珠菌病。
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