Verma Shivani, Sharma Saurabh
Department of Pharmacology, Indo-Soviet Friendship Pharmacy College (ISFCP), Moga, Punjab, India.
Department of Pharmacology, School of Pharmaceutical and Allied Medical Sciences, CT University, Ferozepur Road, Ludhiana, Punjab, India.
Curr Mol Pharmacol. 2018;11(3):191-202. doi: 10.2174/1874467211666180226161846.
Tyrosine-protein phosphatase is an enzyme that functions in a unit with tyrosine kinases to regulate signaling pathways. Several members of the PTP family link to human disease predisposition such as PTP1B, SH2, DEP1, and inhibition of these enzymes may represent an effective palliative therapy.
This review aims to summarize the rapidly developing role of the PTPs in various physiological and pathological states.
Pharmacological inhibition of protein tyrosine phosphatase has been found to reduce endothelial dysfunction in different cardiovascular diseases related to metabolic disorders and it can be helpful for the management of other brain disorders associated with perhaps even in normal, agerelated cognitive decline. Tyrosine-protein phosphates have both stimulatory and inhibitory consequences on cancer-associated signaling pathways and deregulation of PTKs involves tumorgenesis.
Inhibition of protein tyrosine phosphatase plays an important function in the improvement of various diseases such as metabolic, cardiovascular disorders, cancer and autoimmune disease.
酪氨酸蛋白磷酸酶是一种与酪氨酸激酶共同作用以调节信号通路的酶。蛋白酪氨酸磷酸酶（PTP）家族的几个成员与人类疾病易感性相关，如蛋白酪氨酸磷酸酶1B（PTP1B）、含Src同源2结构域蛋白（SH2）、DEP1，抑制这些酶可能是一种有效的姑息治疗方法。
本综述旨在总结PTP在各种生理和病理状态下迅速发展的作用。
已发现蛋白酪氨酸磷酸酶的药理抑制作用可减轻与代谢紊乱相关的不同心血管疾病中的内皮功能障碍，并且它可能有助于管理其他脑部疾病，甚至可能有助于改善正常的与年龄相关的认知衰退。酪氨酸蛋白磷酸酶对癌症相关信号通路具有刺激和抑制作用，酪氨酸激酶的失调涉及肿瘤发生。
抑制蛋白酪氨酸磷酸酶在改善各种疾病（如代谢性疾病、心血管疾病、癌症和自身免疫性疾病）中发挥着重要作用。
