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使用抗凝剂或抗血小板药物的钝性创伤患者发生迟发性颅内出血:无需常规重复头部计算机断层扫描。

Delayed intracranial hemorrhage in the patient with blunt trauma on anticoagulant or antiplatelet agents: routine repeat head computed tomography is unnecessary.

作者信息

Hill Joshua H, Bonner Paul, O'Mara M Shay, Wood Teresa, Lieber Michael

机构信息

a Grant Medical Center , Trauma, an OhioHealth Hospital , Columbus , OH , USA.

b Doctor's Hospital , PGY-2 General Surgery, an OhioHealth Hospital , Columbus , OH , USA.

出版信息

Brain Inj. 2018;32(6):735-738. doi: 10.1080/02699052.2018.1441442. Epub 2018 Feb 27.

DOI:10.1080/02699052.2018.1441442
PMID:29485294
Abstract

OBJECTIVE

We postulate that in patients with blunt trauma on anticoagulant or antiplatelet agents, incidence and complication rate of delayed intracranial hemorrhage (DICH) after an initially negative head CT is low and routine repeat head CT is not warranted.

DESIGN

A retrospective, observational study performed from 2008 to 2012.

PATIENTS

A total of 338 patients with blunt trauma with pre-admission history of any anticoagulant use, who had an initially negative head CT, followed by a repeat CT within 48 hours.

INTERVENTIONS

There were no interventions, this was an observational study only.

MEASUREMENTS AND MAIN RESULTS

The sample had mean ISS of 8.6 and an average GCS of 15. 55% had obvious head trauma, 27.2% reported LOC. Incidence of DICH was 2.4% (8/338). All patients with DICH were taking aspirin (ASA) either alone or in combination with another anticoagulant. Of the eight patients with DICH, none required medical or surgical intervention and there were no mortalities. We identified no significant predictors of delayed ICH.

CONCLUSIONS

Routine repeat head CT in patients with blunt trauma taking anticoagulant or antiplatelet agents is unnecessary. Incidence of DICH is low and, when found, DICH was clinically insignificant. We recommend close supervision in this population, especially those taking ASA alone or in combination with another anticoagulant.

摘要

目的

我们推测,对于服用抗凝剂或抗血小板药物的钝性创伤患者,首次头颅CT检查结果为阴性后迟发性颅内出血(DICH)的发生率和并发症发生率较低,无需常规重复进行头颅CT检查。

设计

2008年至2012年进行的一项回顾性观察研究。

患者

共有338例钝性创伤患者,入院前有任何抗凝剂使用史,首次头颅CT检查结果为阴性,随后在48小时内进行了重复CT检查。

干预措施

无干预措施,这仅是一项观察性研究。

测量指标及主要结果

样本的平均损伤严重度评分(ISS)为8.6,平均格拉斯哥昏迷量表(GCS)评分为15。55%有明显头部创伤,27.2%报告有昏迷史。DICH的发生率为2.4%(8/338)。所有发生DICH的患者均单独服用阿司匹林(ASA)或与另一种抗凝剂联合使用。在8例发生DICH的患者中,无人需要药物或手术干预,也无死亡病例。我们未发现迟发性颅内出血的显著预测因素。

结论

对于服用抗凝剂或抗血小板药物的钝性创伤患者,无需常规重复进行头颅CT检查。DICH的发生率较低,且一旦发现,在临床上无显著意义。我们建议对该人群进行密切监测,尤其是那些单独服用ASA或与另一种抗凝剂联合使用的患者。

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