Kasyap Akhilesh Kumar, Sah Shiv Kumar, Chaudhary Sitaram
Department of Medicine, Gastroenterology unit, National Academy of Medical Science, Bir Hospital Mahabauddha, Kathmandu, Nepal.
Faculty of Pharmaceutical Science, Purbanchal University, Little Buddha College of Health Science, Minbhawan, Kathmandu, Nepal.
PLoS One. 2018 Feb 27;13(2):e0192739. doi: 10.1371/journal.pone.0192739. eCollection 2018.
Gastro esophageal reflux disease (GERD) is a chronic and recurrent disease, and it varies in regions. However, to date, there are no reports available on clinical features and the risk factors for the asymptomatic reflux esophagitis in Nepalese adults.
Data were gathered from 142 erosive patients who had undergone endoscopy at Bir Hospital, Kathmandu. Los Angeles classification was used to grade the severity of the disease. Patients were interviewed to find out the presence of various reflux symptoms.
Based on the Los Angeles classification, the severity of the disease assessed was; grade A 31.8% (31/142), grade B 39.4% (56/142), grade C 33.8% (48/142), and grade D 4.9% (7/142). One hundred and twenty six (88.7%) subjects had reflux symptoms. Prevalence of asymptomatic esophagitis was 16(11.3%). Age was independently linked to asymptomatic esophagitis (P<0.05), and the odd of being asymptomatic appeared lower in younger adults (P<0.05; OR: 0.118; CI: 0.014-.994).
A low prevalence of asymptomatic reflux esophagitis (RE) was seen. Most subjects experienced mild to moderate RE. Age remained an independent factor associated with reflux esophagitis, and the odds of being asymptomatic was lower in younger age.
胃食管反流病（GERD）是一种慢性复发性疾病，且存在地区差异。然而，迄今为止，尚无关于尼泊尔成年人无症状反流性食管炎的临床特征和危险因素的报道。
收集了加德满都比尔医院142例接受内镜检查的糜烂性患者的数据。采用洛杉矶分类法对疾病严重程度进行分级。对患者进行访谈以了解各种反流症状的存在情况。
根据洛杉矶分类法，评估的疾病严重程度为：A级31.8%（31/142），B级39.4%（56/142），C级33.8%（48/142），D级4.9%（7/142）。126名（88.7%）受试者有反流症状。无症状食管炎的患病率为16例（11.3%）。年龄与无症状食管炎独立相关（P<0.05），且年轻人无症状的几率较低（P<0.05；OR：0.118；CI：0.014 - 0.994）。
无症状反流性食管炎（RE）的患病率较低。大多数受试者经历轻度至中度RE。年龄仍然是与反流性食管炎相关的独立因素，且年轻人无症状的几率较低。
