Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.
J Gastroenterol Hepatol. 2012 Apr;27 Suppl 3:53-7. doi: 10.1111/j.1440-1746.2012.07073.x.
Prevalence of gastroesophageal reflux disease (GERD) varies in regions, but few reports on clinical features and quality of life (QOL) of asymptomatic GERD exist in Japan.
Endoscopy was performed in our department between April 2008 and September 2010. Among 6409 cases answering Frequency of Scale for the Symptoms of GERD (FSSG) and SF8 QOL (PCS: physical component summary; MCS: mental component summary), proton pump inhibitor or histamine 2 receptor antagonist users were excluded, and 388 cases diagnosed as reflux esophagitis (RE) (Los Angeles Classification grade A, B, C, D) were analyzed. Asymptomatic cases with FSSG total score = 0 were defined as asymptomatic RE (AsymRE) and FSSG total score ≥ 1 as symptomatic RE (SymRE). Each clinical feature was analyzed.
The frequency of AsymRE was 11.6% of RE (AsymRE, n = 45; SymRE, n = 343). Patient characteristics in AsymRE, SymRE were male/female = 35/10; 239/104 (not significant), mean age (year) = 63.5 ± 14.3; 58.3 ± 12.7 (P < 0.01), body mass index = 23.9 ± 4.3; 23.5 ± 3.7 (ns), respectively. Regarding the grade of RE, grade A 80.0%, B 17.8%, C 2.2% and D 0% in AsymRE, and grade A 72.6%, B 24.8%, C 2.0% and D 0.6% in SymRE (ns). PCS in SF8 was AsymRE; SymRE = 51.8 ± 9.8; 49.0 ± 7.7 (P < 0.01) and MCS in SF8 was AsymRE; SymRE = 51.4 ± 9.4; 48.2 ± 7.6 (P < 0.01), respectively.
The prevalence of asymptomatic RE was high, particularly in elderly subjects. Unlike symptomatic RE, QOL was not impaired at all with asymptomatic RE. No differences were seen between groups in clinical features such as endoscopic severity of RE, indicating that asymptomatic RE is a condition that should not be overlooked clinically.
胃食管反流病（GERD）的患病率在不同地区存在差异，但日本关于无症状 GERD 的临床特征和生活质量（QOL）的报道较少。
我们部门于 2008 年 4 月至 2010 年 9 月进行了内镜检查。在回答了胃食管反流病症状频率量表（FSSG）和 SF8 QOL（PCS：生理成分综合评分；MCS：心理成分综合评分）的 6409 例患者中，排除质子泵抑制剂或组胺 2 受体拮抗剂使用者，并对 388 例诊断为反流性食管炎（RE）（洛杉矶分类等级 A、B、C、D）的患者进行了分析。FSSG 总分=0 的无症状病例被定义为无症状 RE（AsymRE），FSSG 总分≥1 的为有症状 RE（SymRE）。分析了每个临床特征。
RE 中无症状 RE 的发生率为 11.6%（AsymRE，n=45；SymRE，n=343）。AsymRE 和 SymRE 的患者特征为男/女=35/10；239/104（无显著性差异），平均年龄（岁）=63.5±14.3；58.3±12.7（P<0.01），体重指数=23.9±4.3；23.5±3.7（无显著性差异）。关于 RE 的严重程度，AsymRE 中等级 A 为 80.0%，B 为 17.8%，C 为 2.2%，D 为 0%，SymRE 中等级 A 为 72.6%，B 为 24.8%，C 为 2.0%，D 为 0.6%（无显著性差异）。SF8 中的 PCS 为 AsymRE；SymRE=51.8±9.8；49.0±7.7（P<0.01），SF8 中的 MCS 为 AsymRE；SymRE=51.4±9.4；48.2±7.6（P<0.01）。
无症状 RE 的患病率较高，尤其是在老年患者中。与有症状 RE 不同，无症状 RE 的生活质量根本没有受损。两组在 RE 的内镜严重程度等临床特征方面无差异，表明无症状 RE 是一种不应忽视的临床情况。
