加巴喷丁治疗慢性神经性疼痛。
Gabapentin for Chronic Neuropathic Pain.
机构信息
Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England.
出版信息
JAMA. 2018 Feb 27;319(8):818-819. doi: 10.1001/jama.2017.21547.
PMID:29486015
Abstract
CLINICAL QUESTION
Is gabapentin associated with pain relief in people with chronic neuropathic pain?
BOTTOM LINE
Oral gabapentin (1200-3600 mg/d for 4-12 weeks) for patients with moderate or severe neuropathic pain from postherpetic neuralgia (PHN) or painful diabetic neuropathy (PDN) is associated with pain reduction of at least 50% in 14% to 17% more patients than placebo.
摘要
临床问题
加巴喷丁是否能缓解慢性神经性疼痛患者的疼痛？
结论
对于带状疱疹后神经痛（PHN）或糖尿病性神经痛（PDN）所致中重度神经性疼痛患者，口服加巴喷丁（1200-3600mg/d，持续 4-12 周）可使至少 50%疼痛减轻的患者比例比安慰剂组多 14%-17%。
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