倍性在心脏再生中的作用。
A Role for Ploidy in Heart Regeneration.
机构信息
Baylor College of Medicine and Texas Heart Institute, Houston, TX 77030, USA.
Baylor College of Medicine and Texas Heart Institute, Houston, TX 77030, USA.
出版信息
Dev Cell. 2018 Feb 26;44(4):403-404. doi: 10.1016/j.devcel.2018.02.004.
PMID:29486188
Abstract
There is mounting circumstantial evidence that ploidy, a cell's relative DNA content, is in part responsible for the differential cardiac regenerative capacity observed between regenerative and non-regenerative organisms. In this issue of Developmental Cell, González-Rosa et al. (2018) provide direct evidence that polyploid cardiomyocytes have reduced proliferative and regenerative potential.
摘要
越来越多的间接证据表明，ploidy（细胞的相对 DNA 含量）在一定程度上导致了再生组织和非再生组织之间心脏再生能力的差异。在本期《发育细胞》中，González-Rosa 等人（2018）提供了直接证据，表明多倍体心肌细胞的增殖和再生能力降低。
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