细胞非整倍体相关的应激反应。
Cellular Stress Associated with Aneuploidy.
机构信息
Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
出版信息
Dev Cell. 2018 Feb 26;44(4):420-431. doi: 10.1016/j.devcel.2018.02.002.
Abstract
Aneuploidy, chromosome stoichiometry that deviates from exact multiples of the haploid compliment of an organism, exists in eukaryotic microbes, several normal human tissues, and the majority of solid tumors. Here, we review the current understanding about the cellular stress states that may result from aneuploidy. The topics of aneuploidy-induced proteotoxic, metabolic, replication, and mitotic stress are assessed in the context of the gene dosage imbalance observed in aneuploid cells. We also highlight emerging findings related to the downstream effects of aneuploidy-induced cellular stress on the immune surveillance against aneuploid cells.
摘要
非整倍体，即染色体数量偏离生物单倍体整套的精确倍数，存在于真核微生物、几种正常人类组织和大多数实体肿瘤中。在这里，我们综述了目前对可能由非整倍体引起的细胞应激状态的理解。在非整倍体细胞中观察到的基因剂量失衡的背景下，评估了非整倍体引起的蛋白毒性、代谢、复制和有丝分裂应激等方面的内容。我们还强调了与非整倍体诱导的细胞应激对非整倍体细胞免疫监视的下游影响有关的新发现。
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