肿瘤坏死因子α诱导蛋白3（TNFAIP3）信使核糖核酸水平与重度抑郁症患者的心理焦虑相关。
TNFAIP3 mRNA Level Is Associated with Psychological Anxiety in Major Depressive Disorder.
作者信息
Chen Ruei-An, Huang Tiao-Lai, Huang Kai-Wei, Hung Yi-Yung
机构信息
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Department of Nursing, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
出版信息
Neuroimmunomodulation. 2017;24(4-5):271-275. doi: 10.1159/000486860. Epub 2018 Feb 27.
BACKGROUND
Major depressive disorder has been shown to be associated with inflammation and the dysregulation of innate immune responses. Previously, we showed an inverse correlation between the severity of depression and level of TNFAIP3 mRNA expression. The present study further evaluated the association between TNFAIP3 mRNA expression level and symptoms of major depressive disorder (MDD) in 91 patients (20 men and 71 women).
METHODS
The relationships between subscores on the 17-item Hamilton Depression Rating Scale (HAMD-17) and TNFAIP3 mRNA levels were assessed by multiple linear regression.
RESULTS
Only psychological anxiety on the HAMD-17 correlated significantly with TNFAIP3 mRNA expression. Other symptoms, such as depressed mood, insomnia, work and activities, and suicide, were not associated with TNFAIP3 mRNA expression.
CONCLUSION
These findings suggest a significant association between anxiety and TNFAIP3 mRNA levels in patients with MDD.
背景
重度抑郁症已被证明与炎症及先天性免疫反应失调有关。此前，我们发现抑郁症严重程度与TNFAIP3 mRNA表达水平呈负相关。本研究进一步评估了91例患者（20名男性和71名女性）中TNFAIP3 mRNA表达水平与重度抑郁症（MDD）症状之间的关联。
方法
通过多元线性回归评估17项汉密尔顿抑郁量表（HAMD - 17）各分项得分与TNFAIP3 mRNA水平之间的关系。
结果
仅HAMD - 17中的心理焦虑与TNFAIP3 mRNA表达显著相关。其他症状，如情绪低落、失眠、工作及活动和自杀等，与TNFAIP3 mRNA表达无关。
结论
这些发现表明MDD患者的焦虑与TNFAIP3 mRNA水平之间存在显著关联。
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