左旋5-羟色氨酸联合或不联合卡比多巴对血浆β-内啡肽及疼痛感知的影响。对偏头痛预防的潜在意义。

Effects of L-5HTP with and without carbidopa on plasma beta-endorphin and pain perception. Possible implications in migraine prophylaxis.

作者信息

Genazzani A R, Sandrini G, Facchinetti F, Rizzo V, Alfonsi E, Sances G, Calvani M, Nappi G

出版信息

Cephalalgia. 1986 Dec;6(4):241-5. doi: 10.1046/j.1468-2982.1986.0604241.x.

DOI:10.1046/j.1468-2982.1986.0604241.x

Abstract

L-Tryptophan (L-TP) has been used in migraine and other pain conditions. The mechanism underlying the analgesic effect is still partly undefined. In this study the effects of subchronic administration of L-5-hydroxy-tryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers. To measure also an objective indicator for pain, the nociceptive flexion reflex threshold was studied. L-5HTP treatment with and without carbidopa administration increased beta-EP levels significantly (p less than 0.05). L-5HTP plus carbidopa induced an increase in beta-EP significantly (p less than 0.05) higher than that after L-5HTP alone. Neither subjective pain threshold and tolerance nor RIII threshold was modified by either treatment. Our data seem to point to the existence of a complex linkage between plasma opioid levels and pain perception.

摘要

L-色氨酸（L-TP）已被用于治疗偏头痛及其他疼痛病症。其镇痛作用的潜在机制仍部分不明。本研究在7名健康志愿者中，调查了亚慢性给予L-5-羟色氨酸（L-5HTP）（加或不加卡比多巴）对血浆β-内啡肽（β-EP）水平、主观疼痛阈值和耐受性的影响。为了测量疼痛的客观指标，还研究了伤害性屈曲反射阈值。给予L-5HTP加或不加卡比多巴治疗均显著提高了β-EP水平（p<0.05）。L-5HTP加卡比多巴诱导的β-EP升高显著（p<0.05）高于单独给予L-5HTP后的升高。两种治疗均未改变主观疼痛阈值、耐受性及RIII阈值。我们的数据似乎表明血浆阿片类物质水平与疼痛感知之间存在复杂的联系。