T3 声门鳞状细胞癌治疗结果的比较：一项荟萃分析
Comparison of Treatment Outcomes for T3 Glottic Squamous Cell Carcinoma: A Meta-Analysis.
作者信息
Kim Bo Hae, Park Sung Joon, Jeong Woo-Jin, Ahn Soon-Hyun
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, Dongguk University Gyeongju Hospital, Gyeongju, Korea.
Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea.
出版信息
Clin Exp Otorhinolaryngol. 2018 Mar;11(1):1-8. doi: 10.21053/ceo.2017.00717. Epub 2018 Feb 22.
OBJECTIVES
This study compared the survival outcomes, local control rate, and laryngeal preservation rate of various treatment strategies in the treatment of T3 squamous cell carcinoma of the glottis using proportional meta-analyses.
METHODS
Twenty-five retrospective case-series studies were included in these analyses. Treatment strategies were classified as total laryngectomy (TL), open partial laryngectomy (PL), transoral laser microsurgery (TLM), chemo-radiation therapy (CRT), and radiation therapy (RT) alone.
RESULTS
The overall survival rate and disease-specific survival rate among laryngeal preservation treatments did not differ from the overall survival rate of TL. However, the local control rate was lower with RT than TL and PL, and laryngeal preservation rates of TLM and CRT were higher than RT alone.
CONCLUSION
Consideration of preservation of laryngeal function is necessary when treating T3 glottic squamous cell carcinoma. PL, TLM, and, CRT are considered more appropriate initial laryngeal preservation strategies if available.
目的
本研究采用比例Meta分析比较了多种治疗策略在治疗声门型T3鳞状细胞癌时的生存结局、局部控制率和喉保留率。
方法
这些分析纳入了25项回顾性病例系列研究。治疗策略分为全喉切除术（TL）、开放性部分喉切除术（PL）、经口激光显微手术（TLM）、放化疗（CRT）和单纯放疗（RT）。
结果
喉保留治疗的总生存率和疾病特异性生存率与全喉切除术的总生存率无差异。然而，放疗的局部控制率低于全喉切除术和开放性部分喉切除术，经口激光显微手术和放化疗的喉保留率高于单纯放疗。
结论
治疗声门型T3鳞状细胞癌时，有必要考虑保留喉功能。如果可行，开放性部分喉切除术、经口激光显微手术和放化疗被认为是更合适的初始喉保留策略。
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