a Catholic University of Louvain, Société de Recherche pour l'Infertilité (SRI) , Brussels , Belgium.
b Gedeon Richter/Preglem S.A ., Geneva , Switzerland.
Expert Opin Emerg Drugs. 2018 Mar;23(1):17-23. doi: 10.1080/14728214.2018.1446943. Epub 2018 Mar 12.
Uterine fibroids (also known as leiomyomas or myomas) are the most common form of benign uterine tumors. Current management strategies involve mainly surgical interventions, but the choice of treatment is guided by patient age and desire to preserve fertility or avoid 'radical' surgery such as hysterectomy. Areas covered: There is growing evidence of the crucial role of progesterone pathways in the pathophysiology of uterine fibroids, leading to increasing use of selective progesterone receptor modulators (SPRMs) such as ulipristal acetate. We searched all published studies on medical management of fibroids with SPRMs. Expert opinion: The need for alternatives to surgical intervention is very real, especially for women seeking to preserve their fertility. These options now exist, with SPRMs proven to treat fibroid symptoms effectively. Gynecologists now have new tools in their armamentarium, opening up novel strategies for the management of uterine fibroids.
子宫肌瘤（也称为平滑肌瘤或肌瘤）是最常见的良性子宫肿瘤。目前的管理策略主要涉及手术干预，但治疗选择取决于患者的年龄和对保留生育能力或避免子宫切除术等“激进”手术的渴望。涵盖领域：越来越多的证据表明孕激素途径在子宫肌瘤的病理生理学中起着关键作用，这导致越来越多地使用选择性孕激素受体调节剂（SPRMs），如醋酸乌利司他。我们搜索了所有关于 SPRM 治疗子宫肌瘤的医学管理的已发表研究。专家意见：对手术干预替代方案的需求是非常现实的，特别是对于那些希望保留生育能力的女性。这些选择现在已经存在，SPRMs 已被证明可以有效治疗肌瘤症状。妇科医生现在拥有了新的工具，为子宫肌瘤的管理开辟了新的策略。
