Department of Gynecology, Federal University of Piauí, Rua Doutor Anisio Maia, 1261, Ininga, Piauí, 64049-810, Teresina, Brazil.
Reprod Biol Endocrinol. 2021 May 5;19(1):67. doi: 10.1186/s12958-021-00752-x.
Uterine myomas are the most frequent benign solid pelvic tumors in women of reproductive age. At present, uterine myomas are the most common indication for hysterectomy because of the morbidity they cause, including intense bleeding, compression of adjacent organs, pain, and infertility. Some studies show that vitamin D receptor (VDR) expression is correlated with the etiology of uterine leiomyomas. This study aimed to assess the expression of VDR in uterine leiomyoma and nonneoplastic myometrial tissue.
A controlled cross-sectional study involving 40 women who underwent abdominal hysterectomy the Department of Gynecology of the Getúlio Vargas Hospital of Federal University of Piauí, Brazil, was performed to compare the immunohistochemical expression of VDR in samples of uterine leiomyoma tissue with adjacent nonneoplastic myometrial tissue. The mean percetages of stained nuclei in the two groups was compared by Student's t teste, with significance established at p < 0.05.
The percentage of cells with nuclei stained by anti-VDR in the myometrial and leiomyoma tissue was 79.52 % (± 4.32) and 60.22 % (± 7.24), respectively (p < 0.0001).
The mean percentage of nuclei expressing VDR was significantly lower in the uterine leiomyoma than in nonneoplastic myometrial tissue.
子宫肌瘤是生育期妇女最常见的良性盆腔实性肿瘤。目前，由于子宫肌瘤引起的发病率，包括大量出血、邻近器官受压、疼痛和不孕，子宫肌瘤是最常见的子宫切除术指征。一些研究表明，维生素 D 受体（VDR）的表达与子宫肌瘤的病因有关。本研究旨在评估 VDR 在子宫肌瘤和非肿瘤性子宫肌组织中的表达。
对巴西皮奥伊联邦大学格图利奥·瓦加斯医院妇科行腹式子宫切除术的 40 名妇女进行了一项对照性横断面研究，以比较子宫肌瘤组织中 VDR 的免疫组织化学表达与邻近非肿瘤性子宫肌组织。通过 Student's t 检验比较两组染色细胞核的平均百分比，以 p < 0.05 表示差异有统计学意义。
抗 VDR 染色的细胞核在子宫肌层和肌瘤组织中的百分比分别为 79.52%（±4.32）和 60.22%（±7.24）（p<0.0001）。
子宫肌瘤中表达 VDR 的细胞核平均百分比明显低于非肿瘤性子宫肌组织。
