Biner Inci Uslu, Tatci Ebru, Ozyurek Berna Akinci, Ozmen Ozlem
Department of Nuclear Medicine, Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.
Department of Chest Diseases, Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.
Lung India. 2018 Mar-Apr;35(2):157-159. doi: 10.4103/lungindia.lungindia_189_17.
Paclitaxel is frequently used for the treatment of patients with nonsmall cell lung cancer. Hypersensitivity reactions (HSRs) have been one of the toxicities observed with administration of paclitaxel. Here, we presented a case of a 49-year-old man with a history of right lung mass proven by biopsy to be a nonsmall cell lung cancer (squamous cell carcinoma) who developed HSR during therapy. In addition to the hypermetabolic primary malignancy, a positron emission tomography/computed tomography (PET/CT) scan showed multiple hypermetabolic skin lesions at several parts of the body. These cutaneous lesions were resolved in the restaging PET/CT scan performed after completion of the six cycles of chemotherapy. This is the first documented case of comparative PET/CT findings of a paclitaxel-induced hypersensitivity.
紫杉醇常用于治疗非小细胞肺癌患者。过敏反应（HSRs）一直是紫杉醇给药过程中观察到的毒性之一。在此，我们报告了一例49岁男性病例，该患者经活检证实右肺肿块为非小细胞肺癌（鳞状细胞癌），在治疗期间发生了过敏反应。除了高代谢的原发性恶性肿瘤外，正电子发射断层扫描/计算机断层扫描（PET/CT）显示身体多个部位有多个高代谢皮肤病变。在完成六个周期化疗后进行的再次分期PET/CT扫描中，这些皮肤病变消失了。这是第一例有文献记载的紫杉醇诱导过敏反应的PET/CT对比结果病例。
