Department of Pathology Department of Pneumology (PAV I), Aderrahmen's Mami Hospital of Respiratory Diseases, Ariana, Tunis, Tunisia.
J Eur Acad Dermatol Venereol. 2011 Jun;25(6):722-6. doi: 10.1111/j.1468-3083.2010.03818.x. Epub 2010 Aug 23.
The skin is a rare site of metastasis of the internal malignancies. On the contrary, lung cancer is a common primary malignancy of skin metastasis. The latter is either synchronous with the primary lung tumour or can reveal it.
To analyse the clinical findings and the outcome of cutaneous metastasis in patients with primary lung cancer.
Retrospective study including 12 cases of cutaneous metastasis of lung cancer diagnosed in our institution during 6years.
Our patients included three women and nine men with a median age of 59.83years. The cutaneous metastases were unique in seven cases. They revealed the primary tumour in two cases, were discovered synchronously with the primary tumour in six cases and after the primary tumour in four cases. They appeared in patients presenting multiple metastases in 10 cases. Clinical appearance consisted on a firm nodule, sometimes ulcerated with a diameter ranging from 0.5 to 5.5cm. The tumour was sited in the thorax, the back, the abdomen; or the upper or lower limbs. Pathological examination of bronchial biopsy revealed an adenocarcinoma in eight cases, a squamous cell carcinoma in two cases and a small cell carcinoma in two cases. In spite of lung cancer therapies, the patients with metastasis to other organs with a median follow-up time of 4months died.
Cutaneous metastases of lung cancer are of poor prognosis. They are most of the time associated with an advanced neoplastic process with metastasis to other organs. Median survival after skin involvement does not exceed months.
皮肤是内脏恶性肿瘤转移的罕见部位。相反，肺癌是皮肤转移的常见原发性恶性肿瘤。后者要么与原发性肺肿瘤同时发生，要么会揭示它。
分析原发性肺癌患者皮肤转移的临床发现和结果。
回顾性研究包括 6 年内我院诊断的 12 例肺癌皮肤转移患者。
我们的患者包括 3 名女性和 9 名男性，中位年龄为 59.83 岁。7 例患者的皮肤转移是单一的。在 2 例患者中发现了原发性肿瘤，在 6 例患者中与原发性肿瘤同时发现，在 4 例患者中发现原发性肿瘤后。在 10 例出现多发性转移的患者中出现了皮肤转移。临床表现为一个坚实的结节，有时伴有溃疡，直径从 0.5 厘米到 5.5 厘米不等。肿瘤位于胸部、背部、腹部或上肢或下肢。支气管活检的病理检查显示 8 例为腺癌，2 例为鳞状细胞癌，2 例为小细胞癌。尽管进行了肺癌治疗，但有转移到其他器官的患者预后不良，中位随访时间为 4 个月。
肺癌的皮肤转移预后较差。它们通常与转移到其他器官的晚期肿瘤过程有关。皮肤受累后的中位生存时间不超过 4 个月。
