Tokioka H, Miyazaki A, Fung P, Rajagopalan R E, Kar S, Meerbaum S, Corday E, Drury J K
Circulation. 1987 Feb;75(2):473-81. doi: 10.1161/01.cir.75.2.473.
Effects of intracoronary infusion (50 ml/min) of arterial blood, oxygenated or unoxygenated Fluosol, or Plasmalyte A on hemodynamics, electrocardiogram, regional myocardial function, and lactate metabolism were studied in six closed-chest dogs during 2 min occlusions of the left anterior descending coronary artery followed by 10 min of reperfusion. Normal hemodynamics were maintained with infusion of arterial blood and oxygenated Fluosol, whereas unoxygenated Fluosol and Plasmalyte A resulted in hemodynamic deterioration similar to that noted with no treatment. Ischemic zone systolic fractional area change, an index of systolic function measured by two-dimensional echocardiography, remained normal during the occlusion supplemented with intracoronary arterial blood (49 +/- 7%), was moderately hypokinetic with oxygenated Fluosol (31 +/- 10%), and became severely hypokinetic with unoxygenated Fluosol (14 +/- 14%), with Plasmalyte A (2 +/- 13%), and in the absence of treatment (5 +/- 9%). Only infusion of arterial blood resulted in no ST segment elevation or lactate production. Thus intracoronary infusion of arterial blood during brief coronary occlusion maintained normal myocardial function and aerobic metabolism. Infusion of oxygenated Fluosol resulted in amelioration of the decline in regional function after coronary occlusion, but not complete protection.
在六只开胸犬身上，研究了冠状动脉内输注（50毫升/分钟）动脉血、氧合或未氧合的氟碳乳剂或平衡液A对血流动力学、心电图、局部心肌功能和乳酸代谢的影响。在左前降支冠状动脉闭塞2分钟后再灌注10分钟的过程中进行了上述研究。输注动脉血和氧合氟碳乳剂可维持正常的血流动力学，而未氧合的氟碳乳剂和平衡液A则导致血流动力学恶化，与未治疗时相似。缺血区收缩期面积分数变化是通过二维超声心动图测量的收缩功能指标，在冠状动脉内补充动脉血的闭塞过程中保持正常（49±7%），在氧合氟碳乳剂时轻度运动减弱（31±10%），在未氧合氟碳乳剂时严重运动减弱（14±14%），在平衡液A时（2±13%）以及未治疗时（5±9%）也严重运动减弱。只有输注动脉血未导致ST段抬高或乳酸生成。因此，在短暂冠状动脉闭塞期间冠状动脉内输注动脉血可维持正常的心肌功能和有氧代谢。输注氧合氟碳乳剂可改善冠状动脉闭塞后局部功能的下降，但不能提供完全保护。
