Cleman M, Jaffee C C, Wohlgelernter D
Circulation. 1986 Sep;74(3):555-62. doi: 10.1161/01.cir.74.3.555.
Catheter balloon inflation performed during percutaneous transluminal coronary angioplasty (PTCA) results in temporary interruption of coronary blood flow and subsequent myocardial ischemia. This produces transient but profound regional left ventricular dysfunction. In an effort to mitigate this inflation-related dysfunction, oxygenated Fluosol DA 20%, a perfluorochemical oxygen transport fluid, was infused distal to the balloon through the central lumen of the dilating catheter during balloon inflation. Regional wall motion during PTCA was assessed by simultaneous continuous two-dimensional echocardiography and was quantified by computer analysis. During control inflations accompanied by no intracoronary infusion or by transcatheter infusion of Ringer's lactate solution or nonoxygenated Fluosol DA 20%, there was profound regional left ventricular dysfunction with a greater than 90% decrease in regional contraction. In contrast, regional contraction during transcatheter infusion of oxygenated Fluosol DA 20% remained at normal levels throughout balloon inflation. Distal infusion of Fluosol DA 20% during balloon inflation is a useful adjunct to PTCA, allowing longer inflation times and perhaps permitting PTCA to be performed safely in patients with significant myocardium at ischemic risk or with limited left ventricular reserve for whom the procedure is currently believed to be too hazardous.
经皮腔内冠状动脉成形术（PTCA）期间进行的导管球囊充盈会导致冠状动脉血流暂时中断并随后引发心肌缺血。这会产生短暂但严重的局部左心室功能障碍。为了减轻这种与充盈相关的功能障碍，在球囊充盈期间，通过扩张导管的中心腔将20%的含氧全氟萘烷（Fluosol DA），一种全氟化学氧运输液，注入球囊远端。PTCA期间的局部壁运动通过同步连续二维超声心动图进行评估，并通过计算机分析进行量化。在未进行冠状动脉内输注或通过导管输注乳酸林格液或不含氧的20%全氟萘烷的对照充盈期间，存在严重的局部左心室功能障碍，局部收缩下降超过90%。相比之下，在整个球囊充盈过程中，通过导管输注20%含氧全氟萘烷期间的局部收缩保持在正常水平。在球囊充盈期间远端输注20%全氟萘烷是PTCA的一种有用辅助手段，可延长充盈时间，并可能使PTCA能够安全地应用于有显著心肌缺血风险或左心室储备有限的患者，目前认为这些患者进行该手术风险太大。
