使用Amplatzer心脏封堵器和Amplatzer Amulet封堵左心耳：临床试验最新进展
Left Atrial Appendage Occlusion with Amplatzer Cardiac Plug and Amplatzer Amulet: a Clinical Trials Update.
作者信息
Tzikas Apostolos
机构信息
AHEPA University Hospital, Thessaloniki, Greece.
出版信息
J Atr Fibrillation. 2017 Dec 31;10(4):1651. doi: 10.4022/jafib.1651. eCollection 2017 Dec.
Abstract
It has been over a decade since dedicated Amplatzer devices have been used for left atrial appendage occlusion (LAAO) in patients with atrial fibrillation. The first was the Amplatzer Cardiac Plug (ACP) that is now replaced in most countries by the Amplatzer Amulet device. Most of the clinical data for ACP come from the ACP multicenter registry that included 1047 patients from 22 sites, whereas the largest to date report on the Amplatzer Amulet is a recently published prospective multicenter study in 1088 patients from 64 sites. Two important randomized clinical trials the Amulet IDE trial and the STROKECLOSE trial are currently enrolling patients and expected to provide more data on LAAO with Amplatzer Amulet in the near future.
摘要
自专用的Amplatzer装置被用于房颤患者的左心耳封堵术（LAAO）以来，已经过去了十多年。首个装置是Amplatzer心脏封堵器（ACP），如今在大多数国家已被Amplatzer护身符装置所取代。ACP的大多数临床数据来自ACP多中心注册研究，该研究纳入了来自22个地点的1047例患者，而迄今为止关于Amplatzer护身符装置的最大规模报告是最近发表的一项针对来自64个地点的1088例患者的前瞻性多中心研究。两项重要的随机临床试验——护身符器械临床试验（Amulet IDE trial）和STROKECLOSE试验——目前正在招募患者，预计在不久的将来会提供更多关于使用Amplatzer护身符装置进行左心耳封堵术的数据。
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