Vloeberghs Robin, Opmeer Esther M, De Deyn Peter P, Engelborghs Sebastiaan, De Roeck Ellen E
Thomas More Hogeschool, Antwerpen, België.
Referentiecentrum voor Biologische Markers van Dementie, Universiteit Antwerpen, Antwerpen, België.
Tijdschr Gerontol Geriatr. 2018 Jun;49(3):95-102. doi: 10.1007/s12439-018-0248-6. Epub 2018 Feb 27.
In dementia, apathy and depression are often seen as one disorder because of the many overlapping symptoms. However, for therapy a correct differentiation is essential. Moreover, apathy and depression are likely both associated with different cognitive deficits and progression of the disease. In this research we give an overview of cognitive domains associated with apathy and depression in MCI patients and report how often both disorders occur in a population sample.
We administered the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to 117 cognitively healthy controls (GC), 97 patients with mild cognitive impairment (MCI) and 50 patients with dementia (DEM). In addition, the Apathy Evaluation Scale clinical version (AES-C) and the Geriatric Depression Scale (GDS) were administered.
The number of patients with apathy increased with cognitive decline with respectively 3.4%, 10.4% and 41.5% of patients in the GC, MCI and DEM group. The prevalence of isolated depression was highest in the MCI group (18.8%). Correlation analyses in the MCI group showed that apathy and not depression was associated with a deficit in encoding, attention and global cognitive functioning.
The prevalence of apathy and depressive symptoms is different in patients with MCI, DEM and GC, and within the MCI group apathy and depression are associated with different cognitive domains.
在痴呆症中，由于存在许多重叠症状，冷漠和抑郁常被视为一种疾病。然而，对于治疗而言，正确区分至关重要。此外，冷漠和抑郁可能都与不同的认知缺陷及疾病进展相关。在本研究中，我们概述了与轻度认知障碍（MCI）患者的冷漠和抑郁相关的认知领域，并报告了这两种疾病在人群样本中的发生频率。
我们对117名认知健康对照者（GC）、97名轻度认知障碍患者（MCI）和50名痴呆症患者（DEM）进行了可重复神经心理状态评估量表（RBANS）测试。此外，还使用了临床版冷漠评估量表（AES-C）和老年抑郁量表（GDS）。
随着认知功能下降，冷漠患者的数量增加，GC组、MCI组和DEM组患者中分别有3.4%、10.4%和41.5%出现冷漠症状。单纯抑郁的患病率在MCI组中最高（18.8%）。MCI组的相关性分析表明，与编码、注意力和整体认知功能缺陷相关的是冷漠而非抑郁。
MCI患者、DEM患者和GC患者中冷漠和抑郁症状的患病率不同，且在MCI组中，冷漠和抑郁与不同的认知领域相关。
