Institute of Biomedicine, Medical Biochemistry and Genetics, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.
Department of Internal Medicine, Satakunta Central Hospital, Sairaalantie 3, 28500, Pori, Finland.
Br J Pharmacol. 2019 Jan;176(1):5-15. doi: 10.1111/bph.14180. Epub 2018 Apr 2.
Currently, the multifaceted role of the extracellular matrix (ECM) in tumourigenesis has been realized. One ECM macromolecule exhibiting potent oncosuppressive actions in tumourigenesis is decorin, the prototype of the small leucine-rich proteoglycan gene family. The actions of decorin include its ability to function as an endogenous pan-receptor tyrosine kinase inhibitor, a regulator of both autophagy and mitophagy, as well as a modulator of the immune system. In this review, we will discuss these topics in more detail. We also provide a summary of preclinical studies exploring the value of decorin-mediated oncosuppression, as a potential future adjuvant therapy for epithelial cancers. LINKED ARTICLES: This article is part of a themed section on Translating the Matrix. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.1/issuetoc.
目前，细胞外基质（ECM）在肿瘤发生中的多方面作用已经被认识到。在肿瘤发生中表现出强大抗肿瘤作用的一种 ECM 大分子是核心蛋白聚糖，它是小富含亮氨酸的蛋白聚糖基因家族的原型。核心蛋白聚糖的作用包括其作为内源性泛受体酪氨酸激酶抑制剂的功能、自噬和线粒体自噬的调节剂，以及免疫系统的调节剂。在这篇综述中，我们将更详细地讨论这些主题。我们还提供了对核心蛋白聚糖介导的抗肿瘤抑制作用的临床前研究的总结，作为上皮癌潜在的未来辅助治疗。
