Dawoody Nejad Ladan, Biglari Alireza, Annese Tiziana, Ribatti Domenico
Department of Molecular Medicine and Biochemistry Institute, University of Bern, 3012 Bern, Switzerland.
Department of Molecular Medicine and Genetics, Zanjan University of Medical Sciences, 45154 Zanjan, Iran.
Oncol Lett. 2017 Jun;13(6):4475-4480. doi: 10.3892/ol.2017.5960. Epub 2017 Mar 31.
Constitutive activation of nuclear factor-κB (NF-κB) stimulates cell proliferation and metastasis, and inhibits apoptosis in breast cancer. Transforming growth factor-β (TGF-β) signaling pathway is deregulated in breast cancer progression and metastasis. The aim of the present study was to investigate the inhibitory effects of the two small leucine rich proteoglycans fibromodulin (Fmod) and decorin (Dcn), overexpressed using adenovirus gene transfer, on NF-κB-activity and TGF-β1-expression in the highly metastatic 4T1 breast cancer cell line. The results demonstrate that Fmod and Dcn overexpression is associated with NF-κB and TGF-β1 downregulation, and that Fmod promotes this effect more effectively compared with Dcn.
核因子-κB（NF-κB）的组成性激活会刺激乳腺癌细胞的增殖和转移，并抑制其凋亡。转化生长因子-β（TGF-β）信号通路在乳腺癌进展和转移过程中失调。本研究旨在探讨通过腺病毒基因转移过表达的两种富含亮氨酸的小分子蛋白聚糖——纤调蛋白（Fmod）和核心蛋白聚糖（Dcn），对高转移性4T1乳腺癌细胞系中NF-κB活性和TGF-β1表达的抑制作用。结果表明，Fmod和Dcn的过表达与NF-κB和TGF-β1的下调有关，并且与Dcn相比，Fmod能更有效地促进这种作用。
