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基于模型的呼吸气体分析系统 VOCs 生理参数的测定,第 2 部分。

Modeling-based determination of physiological parameters of systemic VOCs by breath gas analysis, part 2.

机构信息

Breath Research Institute, University of Innsbruck, Rathausplatz 4, A-6850 Dornbirn, Austria. Univ.-Clinic for Anesthesia and Intensive Care, Innsbruck Medical University, Anichstr. 35, A-6020 Innsbruck, Austria.

出版信息

J Breath Res. 2018 Apr 4;12(3):036011. doi: 10.1088/1752-7163/aab2b6.

DOI:10.1088/1752-7163/aab2b6
PMID:29488464
Abstract

In a recent paper (Unterkofler et al 2015 J. Breath Res. 9 036002) we presented a simple two compartment model which describes the influence of inhaled concentrations on exhaled breath concentrations for volatile organic compounds (VOCs) with small Henry constants. In this paper we extend this investigation concerning the influence of inhaled concentrations on exhaled breath concentrations for VOCs with higher Henry constants. To this end we extend our model with an additional compartment which takes into account the influence of the upper airways on exhaled breath VOC concentrations.

摘要

在最近的一篇论文(Unterkofler 等人,2015 年,J. Breath Res. 9,036002)中,我们提出了一个简单的双室模型,用于描述亨利常数较小的挥发性有机化合物(VOC)的吸入浓度对呼气中浓度的影响。在本文中,我们扩展了这一研究,探讨了亨利常数较高的 VOC 的吸入浓度对呼气中浓度的影响。为此,我们扩展了我们的模型,增加了一个额外的腔室,以考虑上呼吸道对呼气中 VOC 浓度的影响。

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引用本文的文献

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Modelling of Breath and Various Blood Volatilomic Profiles-Implications for Breath Volatile Analysis.呼吸与各种血液挥发组学特征的建模——对呼吸挥发性分析的启示。
Molecules. 2022 Apr 7;27(8):2381. doi: 10.3390/molecules27082381.
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Target Analysis of Volatile Organic Compounds in Exhaled Breath for Lung Cancer Discrimination from Other Pulmonary Diseases and Healthy Persons.呼出气体中挥发性有机化合物用于鉴别肺癌与其他肺部疾病及健康人的目标分析
Metabolites. 2020 Aug 3;10(8):317. doi: 10.3390/metabo10080317.