铁催化的α,β-不饱和酮的化学选择性还原反应。
Iron-Catalyzed Chemoselective Reduction of α,β-Unsaturated Ketones.
作者信息
Lator Alexis, Gaillard Sylvain, Poater Albert, Renaud Jean-Luc
机构信息
Normandie Univ., LCMT, ENSICAEN, UNICAEN, CNRS, 6 boulevard du Maréchal Juin, 14050, Caen, France.
Departament de Química, Institut de Química Computacional i Catàlisi (IQCC), Universitat de Girona, Campus de Montilivi, 17003, Girona, Catalonia, Spain.
出版信息
Chemistry. 2018 Apr 17;24(22):5770-5774. doi: 10.1002/chem.201800995. Epub 2018 Mar 22.
An iron-catalyzed chemo- and diastereoselective reduction of α,β-unsaturated ketones into the corresponding saturated ketones in mild reaction conditions is reported herein. DFT calculations and experimental work underline that transfer hydride reduction is a more facile process than hydrogenation, unveiling the fundamental role of the base.
本文报道了一种铁催化的化学和非对映选择性还原反应，可在温和的反应条件下将α,β-不饱和酮还原为相应的饱和酮。密度泛函理论（DFT）计算和实验工作表明，转移氢化还原比氢化反应更容易进行，揭示了碱的重要作用。
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