1 Department of Radiology and Medical Imaging, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229-3026.
AJR Am J Roentgenol. 2018 May;210(5):989-997. doi: 10.2214/AJR.17.19219. Epub 2018 Feb 28.
Screening the cavum septi pellucidi (CSP), more commonly referred to as the "cavum septum pellucidum," is a required component of the fetal anatomic survey during second-trimester ultrasound (US). The inability to identify the normal appearance of this structure warrants further evaluation because septal insufficiency is associated with multiple brain malformations. In this article, we discuss embryology, normal anatomy, and prenatal evaluation of the CSP as well as the differential diagnosis of associated abnormalities.
The CSP is an essential part of the CNS evaluation on second-trimester US; if its normal appearance cannot be confirmed by 20 weeks' gestational age, further evaluation is warranted. Fetal MRI, in either the second or third trimester, has become an important tool in further characterization of the associated abnormalities. However, when fetal MRI is not possible, postnatal MRI can also be used and will help to differentiate primary from secondary absence and will aid in providing prognostic information and therapeutic options for patients.
筛查通常被称为“透明隔腔”的间隔腔（CSP）是中孕期超声（US）胎儿解剖检查的必需组成部分。无法识别该结构的正常外观需要进一步评估，因为隔肌不全与多种脑畸形有关。在本文中，我们讨论了胚胎学、正常解剖结构和 CSP 的产前评估，以及相关异常的鉴别诊断。
CSP 是中孕期 US 中枢神经系统评估的重要组成部分；如果在 20 周妊娠龄时不能确定其正常外观，则需要进一步评估。胎儿 MRI，无论是在第二还是第三孕期，已成为进一步描述相关异常的重要工具。然而，当无法进行胎儿 MRI 时，也可以使用产后 MRI，这将有助于区分原发性和继发性缺失，并为患者提供预后信息和治疗选择。
