Berman A, Winkelmann R K
J Cutan Pathol. 1980 Feb;7(1):32-8. doi: 10.1111/j.1600-0560.1980.tb00974.x.
Seborrheic keratoses in five patients were rubbed and biopsied at varying intervals after injury. Microscopic examination revealed acute and chronic patterns of histologic change. Hemorrhage, hyalinization of dermal papillae, and necrosis of epithelial tips were conspicuous early changes. Specimens taken more than 48 h after rubbing showed a spectrum of changes which included: loss of epithelial mass, expansion and interconnection of keratin cysts, thinning of the epithelium, proliferation of epithelial strands from the residual epithelium, increase in size of epithelial cells, and evidence of hair follicle relationships including trichostasis spinulosa and, in one specimen, hair germ proliferation. Dermal lymphocytic infiltration was variable and only rarely involved the epithelium. These observations demonstrate a patterned response of the seborrheic keratosis to trauma, and also indicate a relationship between seborrheic keratosis and the hair follicle.
对5例患者的脂溢性角化病在损伤后的不同时间间隔进行摩擦并活检。显微镜检查显示出组织学变化的急性和慢性模式。出血、真皮乳头玻璃样变以及上皮尖端坏死是早期明显的变化。摩擦后48小时以上获取的标本显示出一系列变化，包括：上皮团块丢失、角质囊肿扩大和相互连接、上皮变薄、残留上皮的上皮条索增生、上皮细胞大小增加，以及毛囊关系的证据，包括棘状毛周角化病，并且在一个标本中出现毛胚增殖。真皮淋巴细胞浸润情况不一，仅很少累及上皮。这些观察结果证明了脂溢性角化病对创伤的模式化反应，也表明了脂溢性角化病与毛囊之间的关系。
