Modelling and Economics Unit, National Infection Service, Public Health England, London, UK.
PharmacoTherapy, -Epidemiology & -Economics, Department of Pharmacy, University of Groningen, Groningen, The Netherlands.
J Antimicrob Chemother. 2018 Feb 1;73(suppl_2):19-26. doi: 10.1093/jac/dkx502.
Previous work based on guidelines and expert opinion identified 'ideal' prescribing proportions-the overall proportion of consultations that should result in an antibiotic prescription-for common infectious conditions. Here, actual condition-specific prescribing proportions in primary care in England were compared with ideal prescribing proportions identified by experts.
All recorded consultations for common infectious conditions (cough, bronchitis, exacerbations of asthma or chronic obstructive pulmonary disease, sore throat, rhinosinusitis, otitis media, lower respiratory tract infection, upper respiratory tract infection, influenza-like illness, urinary tract infection, impetigo, acne, gastroenteritis) for 2013-15 were extracted from The Health Improvement Network (THIN) database. The proportions of consultations resulting in an antibiotic prescription were established, concentrating on acute presentations in patients without relevant comorbidities. These actual prescribing proportions were then compared with previously established 'ideal' proportions by condition.
For most conditions, substantially higher proportions of consultations resulted in an antibiotic prescription than was deemed appropriate according to expert opinion. An antibiotic was prescribed in 41% of all acute cough consultations when experts advocated 10%. For other conditions the proportions were: bronchitis (actual 82% versus ideal 13%); sore throat (actual 59% versus ideal 13%); rhinosinusitis (actual 88% versus ideal 11%); and acute otitis media in 2- to 18-year-olds (actual 92% versus ideal 17%). Substantial variation between practices was found.
This work has identified substantial overprescribing of antibiotics in English primary care, and highlights conditions where this is most pronounced, particularly in respiratory tract conditions.
基于指南和专家意见的先前工作确定了“理想”的处方比例 - 应该导致抗生素处方的咨询的总体比例 - 对于常见的传染病。在这里,将英国初级保健中实际特定疾病的处方比例与专家确定的理想处方比例进行了比较。
从健康改善网络(THIN)数据库中提取了 2013-15 年所有常见传染病(咳嗽、支气管炎、哮喘或慢性阻塞性肺疾病加重、喉咙痛、鼻-鼻窦炎、中耳炎、下呼吸道感染、上呼吸道感染、流感样疾病、尿路感染、脓疱病、痤疮、肠胃炎)的记录咨询。确定导致抗生素处方的咨询比例,专注于无相关合并症的急性表现。然后根据条件将这些实际处方比例与先前建立的“理想”比例进行比较。
对于大多数疾病,与专家意见认为适当的比例相比,咨询中开具抗生素的比例大大升高。在所有急性咳嗽咨询中,有 41%的患者开具了抗生素,而专家建议的比例为 10%。对于其他疾病,比例为:支气管炎(实际 82%比理想 13%);喉咙痛(实际 59%比理想 13%);鼻-鼻窦炎(实际 88%比理想 11%);以及 2-18 岁急性中耳炎(实际 92%比理想 17%)。实践之间存在很大差异。
这项工作发现英国初级保健中抗生素的过度处方现象严重,突出了最明显的疾病,特别是呼吸道疾病。