Department of Anatomy-Histology-Embryology, Medical School, University of Ioannina, Ioannina, Greece.
Department of Anatomy-Histology-Embryology, Medical School, University of Ioannina, Ioannina, Greece; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Mech Ageing Dev. 2019 Jan;177:88-90. doi: 10.1016/j.mad.2018.02.005. Epub 2018 Feb 25.
Cellular senescence, an age-related process in response to damage and stress, also occurs during normal development and adult life. The thymus is a central lymphoepithelial organ of the immune system that exhibits age-related changes termed thymic involution. Since the mechanisms regulating thymic involution are still not well elucidated, we questioned whether cellular senescence is implicated in this process. We demonstrate, for the first time in situ, that cellular senescence occurs during human thymic involution using SenTraGor™, a novel chemical compound that is applicable in archival tissue material, providing thus further insights in thymus histophysiology.
细胞衰老，一种与年龄相关的应对损伤和应激的过程，也发生在正常发育和成年期。胸腺是免疫系统的中央淋巴上皮器官，表现出称为胸腺萎缩的与年龄相关的变化。由于调节胸腺萎缩的机制仍未得到很好的阐明，我们质疑细胞衰老是否与这一过程有关。我们首次使用 SenTraGor™，一种可应用于存档组织材料的新型化学化合物，在原位证明了细胞衰老发生在人类胸腺萎缩过程中，从而为胸腺组织生理学提供了更深入的见解。
